{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:55:12Z","timestamp":1777859712365,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little evidence is available regarding the choice of empiric antibiotic therapy in elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The primary objective of this study is to compare the outcomes of elderly patients receiving broad- versus narrow-spectrum antibiotics during hospitalization for AECOPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A multicenter, retrospective, cohort analysis was performed. Inpatients 65 years and older with a primary discharge diagnosis of AECOPD who received \u226548 hours of antibiotic therapy were included in the study population. Patients were compared based on the spectrum of their antibiotic therapy. Narrow-spectrum antibiotics included: azithromycin, doxycycline, sulfamethoxazole\/trimethoprim, or aminopenicillin. The primary outcome was a composite of mechanical ventilation 48 hours after admission, transfer to the intensive care unit 48 hours after admission, 30-day chronic obstructive pulmonary disease (COPD) readmission, and oxygen saturation less than 90% on room air or increased oxygen requirements from baseline 48 hours after admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred fifty-three patients were included in this analysis; 127 patients were included in the narrow-spectrum group, and 126 patients were included in the broad-spectrum group. Patient demographics and comorbid conditions were similarly distributed in each group. The incidence of the primary composite outcome occurred in 50 (39.3%) and 60 (47.6%) of patients in the narrow- and broad-spectrum groups, respectively ( P = .19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>No difference was found in the primary outcome in inpatients aged \u226565 years with AECOPD who received empiric broad-spectrum or narrow-spectrum antibiotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190020938190","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T05:48:51Z","timestamp":1594360131000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Narrow-Versus Broad-Spectrum Antibiotics in Elderly Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-1459","authenticated-orcid":false,"given":"Kayla R.","family":"Joyner","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Shenandoah University Bernard J. Dunn School of Pharmacy, Winchester VA, USA"},{"name":"Department of Pharmacy Services, Valley Health Winchester Medical Center, Winchester, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-3139","authenticated-orcid":false,"given":"Autumn","family":"Walkerly","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Northeast Ohio Medical University, Rootstown, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Seidel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Northeast Ohio Medical University, Rootstown, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Northeast Ohio Medical University, Rootstown, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Damshekan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Northeast Ohio Medical University, Rootstown, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Northeast Ohio Medical University, Rootstown, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7657-3399","authenticated-orcid":false,"given":"Mate M.","family":"Soric","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Northeast Ohio Medical University, Rootstown, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"bibr1-0897190020938190","unstructured":"Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2020. Accessed December 23, 2020. http:\/\/www.goldcopd.org"},{"key":"bibr2-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00002610"},{"key":"bibr3-0897190020938190","first-page":"235","volume":"5","author":"Guarascio AJ","year":"2013","journal-title":"Clinicoecon Outcomes Res"},{"key":"bibr4-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1155\/2003\/486285"},{"key":"bibr5-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17509280"},{"key":"bibr6-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.045930"},{"key":"bibr7-0897190020938190","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S80926"},{"issue":"1","key":"bibr8-0897190020938190","first-page":"31","volume":"3","author":"Siddiqi A","year":"2008","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"bibr9-0897190020938190","volume-title":"Chronic Obstructive Pulmonary Disease Among Adults Aged 18 and Over in the United States, 1998-2009. NCHS Data Brief, No 63","author":"Akinbami LJ","year":"2011"},{"key":"bibr10-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0149"},{"key":"bibr11-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.2.459"},{"key":"bibr12-0897190020938190","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-12-200606200-00006"},{"key":"bibr13-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.05.023"},{"key":"bibr14-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02042-3"},{"key":"bibr15-0897190020938190","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-15"},{"key":"bibr16-0897190020938190","unstructured":"US Food and Drug Administration. FDA Drug Safety Communication: FDA Updates Warnings for Oral and Injectable Fluoroquinolone Antibiotics Due to Disabling Side Effects. 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