{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:13:03Z","timestamp":1780891983010,"version":"3.54.1"},"reference-count":110,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Immunoglobulin G (IgG) is a commonly used treatment for chronic neuromuscular disorders (NMDs), such as chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. IgG therapy has also shown promise in treating other NMDs including myasthenia gravis, polymyositis, and dermatomyositis. IgG is administered as either intravenous immunoglobulin (IVIg) or subcutaneous immunoglobulin (SCIg), with SCIg use becoming more popular due to the treatment burden associated with IVIg. IVIg requires regular venous access; long infusions (typically 4-6 hours); and can result in systemic adverse events (AEs) for some patients. In contrast, SCIg can be self-administered at home with shorter infusions (approximately 1 hour) and fewer systemic AEs. As patient care shifts toward home-based settings, the role of the pharmacist is paramount in providing a continuation of care and acting as the bridge between patient and clinic. Pharmacists with a good understanding of current recommendations, dosing strategies, and administration routes for IgG therapy are best placed to support patients. The aims of this review are to highlight the evidence supporting IgG therapy in the treatment of NMDs and provide practical information on patient management and IVIg\/SCIg dosing in order to guide pharmacists on optimizing clinical outcomes and patient care.<\/jats:p>","DOI":"10.1177\/0897190020938212","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T08:01:16Z","timestamp":1594972876000},"page":"106-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Expanding the Role of the Pharmacist: Immunoglobulin Therapy and Disease Management in Neuromuscular Disorders"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-0416","authenticated-orcid":false,"given":"Eric M.","family":"Tichy","sequence":"first","affiliation":[{"name":"Pharmacy Supply Solutions, Supply Chain Management, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Prosser","sequence":"additional","affiliation":[{"name":"Soleo Health, Sharon Hill, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Doyle","sequence":"additional","affiliation":[{"name":"Soleo Health, Sharon Hill, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"bibr1-0897190020938212","doi-asserted-by":"publisher","DOI":"10.2174\/157015911796558000"},{"key":"bibr2-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2018.1446188"},{"key":"bibr3-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0b013e3182a78ecf"},{"key":"bibr4-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0000000000000248"},{"key":"bibr5-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21433"},{"key":"bibr6-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824de293"},{"key":"bibr7-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1159\/000363445"},{"key":"bibr8-0897190020938212","doi-asserted-by":"publisher","DOI":"10.2217\/imt.13.146"},{"key":"bibr9-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04027.x"},{"key":"bibr10-0897190020938212","unstructured":"FDA. Vivaglobin approval. 2006. Accessed August 15, 2019. https:\/\/www.fda.gov\/biologicsbloodvaccines\/bloodbloodproducts\/approvedproducts\/licensedproductsblas\/fractionatedplasmaproducts\/ucm089394.htm"},{"key":"bibr11-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30378-2"},{"key":"bibr12-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1177\/1756285614563056"},{"key":"bibr13-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12513"},{"key":"bibr14-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2011.00330.x"},{"key":"bibr15-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7444-2"},{"key":"bibr16-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12080"},{"key":"bibr17-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25409"},{"key":"bibr18-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004365"},{"key":"bibr19-0897190020938212","first-page":"458231","volume":"2014","author":"Patrick C","year":"2014","journal-title":"Case Rep Rheumatol"},{"key":"bibr20-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-1940-5"},{"key":"bibr21-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.09.004"},{"key":"bibr22-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.03.010"},{"key":"bibr23-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2009.00218.x"},{"issue":"6","key":"bibr24-0897190020938212","first-page":"S105","volume":"25","author":"Vaughan LJ","year":"2019","journal-title":"Am J Manag Care"},{"key":"bibr25-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K037"},{"key":"bibr26-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0391-5"},{"issue":"1","key":"bibr27-0897190020938212","first-page":"CD010369","volume":"1","author":"Oaklander AL","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr28-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.03.026"},{"key":"bibr29-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612457215"},{"key":"bibr30-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.065441"},{"key":"bibr31-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.6.1617"},{"key":"bibr32-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2014.01.001"},{"key":"bibr33-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824e8f84"},{"key":"bibr34-0897190020938212","first-page":"201657","volume":"2014","author":"Ripellino P","year":"2014","journal-title":"Autoimmune Dis"},{"key":"bibr35-0897190020938212","unstructured":"Behring C. Hizentra US prescribing information revised. March 2018. Accessed August 15, 2019. http:\/\/labeling.cslbehring.com\/PI\/US\/Hizentra\/EN\/Hizentra-Prescribing-Information.pdf"},{"key":"bibr36-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.01.070"},{"key":"bibr37-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1177\/1756285615584739"},{"key":"bibr38-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13218"},{"key":"bibr39-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0026-3"},{"key":"bibr40-0897190020938212","first-page":"567","volume":"10","author":"Lawson VH","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"key":"bibr41-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000605"},{"key":"bibr42-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0023-6"},{"key":"bibr43-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310097"},{"key":"bibr44-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00290.x"},{"key":"bibr45-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9408-3"},{"key":"bibr46-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.01.061"},{"key":"bibr47-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.04.039"},{"key":"bibr48-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02568.x"},{"key":"bibr49-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25107"},{"key":"bibr50-0897190020938212","first-page":"874680","volume":"2012","author":"Jayam Trouth A","year":"2012","journal-title":"Autoimmune Dis"},{"key":"bibr51-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12217"},{"key":"bibr52-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-129"},{"key":"bibr53-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002790"},{"key":"bibr54-0897190020938212","first-page":"CD002277","volume":"12","author":"Gajdos P","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr55-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.971757"},{"key":"bibr56-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24259"},{"key":"bibr57-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159993"},{"issue":"16","key":"bibr58-0897190020938212","first-page":"P3","volume":"86","author":"Siddiqi Z","year":"2016","journal-title":"Neurology"},{"key":"bibr59-0897190020938212","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00064"},{"key":"bibr60-0897190020938212","unstructured":"The Myositis Association. 2019. Accessed August 15, 2019. https:\/\/www.myositis.org\/"},{"key":"bibr61-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-017-0240-6"},{"key":"bibr62-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.12.053"},{"key":"bibr63-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0360"},{"key":"bibr64-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20325"},{"issue":"10","key":"bibr65-0897190020938212","first-page":"2498","volume":"27","author":"Al-Mayouf SM","year":"2000","journal-title":"J Rheumatol"},{"key":"bibr66-0897190020938212","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01299"},{"key":"bibr67-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.033"},{"issue":"2","key":"bibr68-0897190020938212","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/1817-1745.92858","volume":"6","author":"Kaarthigeyan K","year":"2011","journal-title":"J Pediatr Neurosci"},{"key":"bibr69-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-9-28"},{"key":"bibr70-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.05.035"},{"key":"bibr71-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1159\/000354893"},{"key":"bibr72-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12287"},{"key":"bibr73-0897190020938212","doi-asserted-by":"publisher","DOI":"10.2147\/IJCTM.S94329"},{"key":"bibr74-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-016-0192-3"},{"key":"bibr75-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834c22da"},{"key":"bibr76-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12428"},{"key":"bibr77-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13727"},{"key":"bibr78-0897190020938212","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2018-0036"},{"key":"bibr79-0897190020938212","first-page":"163","volume":"2","author":"Wasserman RL","year":"2008","journal-title":"Patient Prefer Adherence"},{"key":"bibr80-0897190020938212","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.164940"},{"key":"bibr81-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60220-8"},{"key":"bibr82-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi111"},{"key":"bibr83-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAN.0000313655.65410.4e"},{"key":"bibr84-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24526"},{"key":"bibr85-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12517"},{"key":"bibr86-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0243-z"},{"key":"bibr87-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.023"},{"issue":"3","key":"bibr88-0897190020938212","first-page":"177","volume":"78","author":"Bush PW","year":"2017","journal-title":"N C Med J"},{"key":"bibr89-0897190020938212","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2016-0058"},{"key":"bibr90-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1177\/1756285616629869"},{"key":"bibr91-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318208824b"},{"key":"bibr92-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8072-9"},{"key":"bibr93-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-016-0349-2"},{"key":"bibr94-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000527"},{"key":"bibr95-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24109"},{"key":"bibr96-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2012.01201.x"},{"key":"bibr97-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-23"},{"key":"bibr98-0897190020938212","unstructured":"Ho C MS, Cimon K, Roifman C, et al. Overview of Subcutaneous Versus Intravenous Immunoglobulin for Primary Immunodeficiencies: Systematic Review and Economic Analysis. [Technology overview number 36]. Canadian Agency for Drugs and Technologies in Health. 2008;36."},{"key":"bibr99-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.08.007"},{"key":"bibr100-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0094-3"},{"key":"bibr101-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03019.x"},{"key":"bibr102-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"bibr103-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2013.01.001"},{"key":"bibr104-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316427"},{"key":"bibr105-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25720"},{"key":"bibr106-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0298-1"},{"key":"bibr107-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"},{"key":"bibr108-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"key":"bibr109-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1177\/1756285617721092"},{"key":"bibr110-0897190020938212","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.33"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190020938212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190020938212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190020938212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:06Z","timestamp":1777509366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190020938212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,17]]},"references-count":110,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/0897190020938212"],"URL":"https:\/\/doi.org\/10.1177\/0897190020938212","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,17]]}}}