{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:11:09Z","timestamp":1783609869064,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early appropriate antibiotic administration is associated with improved outcomes in infectious illnesses. During drug shortages in 2017, the American Society of Health-System Pharmacists recommended intravenous push (IVP) administration of medications when possible to conserve small-volume parenteral solutions. Data supporting IVP penicillins and carbapenems was limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The primary objective of this study compared time from patient emergency department (ED) arrival to antibiotic administration between IVP and intravenous piggy-back (IVPB) administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center pre-post protocol study assessed changes in administration timing and safety of ampicillin\/sulbactam, piperacillin\/tazobactam, and ertapenem from 2015-2018. Medication administration by IVPB (pre) or IVP (post), ED arrival, antibiotic order and administration times, potential effectors of administration time, and safety events were assessed. Acquisition costs were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 696 administrations were included, with 351 and 345 subjects in the IVPB and IVP cohorts, respectively. The median time from ED arrival to initiation of antibiotic administration was 140 (IQR 87-221) minutes and 110 (IQR 68-181) minutes in the IVPB and IVP cohorts, respectively, (P &lt; 0.01). IVP administration increased the proportion of indexed antibiotics administered within 60 minutes of ED arrival compared to IVPB (20% vs. 12%, respectively, P &lt; 0.01). There was no difference in adverse events between both cohorts. Supply acquisition cost savings totaled an more than $5,000 with the IVP protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IVP administration of ampicillin\/sulbactam, piperacillin\/tazobactam, and ertapenem improved times to initiation of empiric, first-dose antibiotics in the ED without an increase in adverse events, saving over $5,000 annually.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0897190020977758","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T13:55:43Z","timestamp":1607694943000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of First-Dose, Intravenous Push Penicillins and Carbapenems in the Emergency Department"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7514-1754","authenticated-orcid":false,"given":"Emmeline C.","family":"Academia","sequence":"first","affiliation":[{"name":"Hematology\/Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Jenrette","sequence":"additional","affiliation":[{"name":"University of Colorado Hospital, Aurora, CO, USA"},{"name":"University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Mueller","sequence":"additional","affiliation":[{"name":"University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA"},{"name":"Medical Intensive Care, University of Colorado Hospital, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"University of Colorado Hospital, Aurora, CO, USA"},{"name":"Emergency Medicine, University of Colorado Hospital, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"bibr1-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2008.01.004"},{"key":"bibr2-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2613-4"},{"key":"bibr3-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000330"},{"key":"bibr4-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003119"},{"issue":"3","key":"bibr5-0897190020977758","first-page":"181","volume":"8","author":"Marshall JC","year":"2006","journal-title":"Crit Care Resusc"},{"key":"bibr6-0897190020977758","unstructured":"American Society of Health-Systems Pharmacists\u2019 Center for Medication Safety and Quality. Small-Volume parenteral solutions shortages. American Society of Health-Systems Pharmacists (ASHP). Shortage Resources. Accessed June 27, 2020. https:\/\/www.ashp.org\/Drug-Shortages\/Shortage-Resources\/Publications\/Small-Volume-Parenteral-Solutions-Shortages?loginreturnUrl=SSOCheckOnly"},{"key":"bibr7-0897190020977758","unstructured":"Zosyn (piperacillin\/tazobactam): Full Prescribing Information. Wyeth Pharmaceuticals Inc; 2017."},{"key":"bibr8-0897190020977758","unstructured":"Unasyn (ampicillin\/sulbactam): Full Prescribing Information. Pfizer Inc; 2017."},{"key":"bibr9-0897190020977758","unstructured":"Invanz (ertapenem): Full Prescribing Information. Merck Sharp and Dohme Corp; 2017."},{"key":"bibr10-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1197"},{"key":"bibr11-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1097\/TME.0000000000000160"},{"key":"bibr12-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1177\/0018578718760257"},{"key":"bibr13-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1177\/0897190017734442"},{"key":"bibr14-0897190020977758","unstructured":"Epic Electronic Health Record Copyright \u00a9 2019. Epic Systems Corporation."},{"key":"bibr15-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"bibr16-0897190020977758","unstructured":"SAS\/STAT Copyright \u00a9 2019. SAS Institute Inc."},{"key":"bibr17-0897190020977758","unstructured":"JMP\n                      \u00ae\n                      , Version 14.1. SAS Institute Inc; 1989-2019."},{"key":"bibr18-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000217961.75225.E9"},{"key":"bibr19-0897190020977758","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cc4824"},{"key":"bibr20-0897190020977758","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150883"},{"key":"bibr21-0897190020977758","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2018.27.14.S4"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190020977758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0897190020977758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0897190020977758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:25Z","timestamp":1777509385000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0897190020977758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1177\/0897190020977758"],"URL":"https:\/\/doi.org\/10.1177\/0897190020977758","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]}}}