{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:39:23Z","timestamp":1787945963052,"version":"build-2784847793"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of this drug review was to explore the safety and efficacy of the newly approved benzodiazepine, remimazolam, in order to evaluate its place in therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>Remimazolam has a faster onset of action and recovery time than midazolam when given as single IV doses. Additionally, it has no known CYP450 interactions that would contribute to drug-drug interactions. Patients with severe hepatic impairment may require dose titration as well as the elderly who should be closely monitored. Although remimazolam vials should be protected from light and must be reconstituted immediately before use, the reconstituted vial may be stored for later use at room temperature for up to 8 hours. Remimazolam is more expensive than current options used in practice, as such individual institutional formulary and provider preference will require review to see if its advantages are worth the additional cost and to determine its place in therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Remimazolam is a novel option when choosing a benzodiazepine for procedural sedation that has pharmacokinetic and pharmacodynamic advantages when compared to other commonly prescribed sedatives. Remimazolam has proved superior to midazolam when analyzing drug-drug interactions, onset, and time to alertness. Remimazolam also has a shorter elimination half-life and decreased volume of distribution when compared to midazolam.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08971900211027303","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T05:32:46Z","timestamp":1624339966000},"page":"149-154","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Remimazolam: A Novel Option for Procedural Sedation in High Risk Patients"],"prefix":"10.1177","volume":"36","author":[{"given":"Megan M.","family":"Pantos","sequence":"first","affiliation":[{"name":"Western New England University, College of Pharmacy and Health Sciences, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Western New England University, College of Pharmacy and Health Sciences, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7794-6732","authenticated-orcid":false,"given":"Eric C.","family":"Nemec","sequence":"additional","affiliation":[{"name":"Sacred Heart University, College of Health Professions, Fairfield, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"bibr1-08971900211027303","volume-title":"Basic & Clinical Pharmacology","volume":"15","author":"Eilers H","year":"2020"},{"key":"bibr2-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002043"},{"key":"bibr3-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000885"},{"key":"bibr4-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000652"},{"key":"bibr5-08971900211027303","unstructured":"U.S. Food and Drug Administration. Drugs@FDA: Midazolam. Published 2021. Accessed June 15, 2021. https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.Cfm?event=overview.process&ApplNo=018654"},{"key":"bibr6-08971900211027303","unstructured":"Midazolam injection, USP. Lake Zurich, IL: Fresenius Kabi; 2017."},{"key":"bibr7-08971900211027303","unstructured":"Novel Drug Approvals for 2020. U.S. food & drug administration. Published 2020. Accessed June 15, 2021. https:\/\/www.fda.gov\/drugs\/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products\/novel-drug-approvals-2020"},{"key":"bibr8-08971900211027303","unstructured":"BYFAVO\u2122 (remimazolam) for injection. Indianapolis, IN: Acacia Pharma; 2020."},{"key":"bibr9-08971900211027303","volume-title":"Lexi-Drugs [database on the Internet]","author":"Midazolam","year":"2021"},{"key":"bibr10-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.04.2351"},{"key":"bibr11-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.09.015"},{"key":"bibr12-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.10.039"},{"issue":"6","key":"bibr13-08971900211027303","first-page":"38","volume":"79","author":"Abouleish AE","year":"2015","journal-title":"ASA Newsletter"},{"key":"bibr14-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-020-02788-6"},{"key":"bibr15-08971900211027303","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-020-02755-1"},{"key":"bibr16-08971900211027303","volume-title":"Lexi-Drugs\u00a0[database on the Internet]","author":"Remimazolam","year":"2021"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900211027303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900211027303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900211027303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:50Z","timestamp":1777509410000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900211027303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1177\/08971900211027303"],"URL":"https:\/\/doi.org\/10.1177\/08971900211027303","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]}}}