{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:59:19Z","timestamp":1787979559206,"version":"build-2784847793"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Background: Deferasirox has proved good efficacy and acceptable safety for the management of thalassaemia patients. However, some patients are unresponsive or intolerant to once-daily administration of deferasirox even at a high dose. The current study evaluated the effectiveness and tolerability of twice-daily dosing of deferasirox among transfusion-dependent paediatric beta-thalassaemia patients. Methods: This prospective randomized single-blinded parallel study included all transfusion-dependent paediatric beta-thalassaemia patients prescribed with deferasirox, who visit the study site for their regular blood transfusions and follow-up. The enrolled patients were randomized into intervention and control groups by using a simple block randomization method. In the intervention group, the once-daily dosing of deferasirox was changed to twice-daily dosing with the same total daily dose. Whereas, in the control group, the patients continued with the once-daily deferasirox dosing. The serum ferritin levels of both groups were determined on the enrolment day and after 6 months of follow-up. Results: Forty-one patients were included for analysis. A statistically significant mean decrease in serum ferritin levels was detected in the intervention group, while the serum ferritin levels of the control group significantly increased from baseline. The twice-daily dosing of deferasirox was better tolerated by the thalassaemia patients when compared to once-daily dosing. Conclusion: This study concludes that twice-daily dosing of deferasirox with the same total daily dose significantly enhances the iron chelation efficacy and tolerability among transfusion-dependent paediatric beta-thalassaemia patients when compared to once-daily regimen.<\/jats:p>","DOI":"10.1177\/08971900211038301","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T03:07:54Z","timestamp":1651028874000},"page":"749-755","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Tolerability of Twice-Daily Dosing Schedule of Deferasirox in Transfusion-Dependent Paediatric Beta-Thalassaemia Patients: A Randomized Controlled Study"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-7413","authenticated-orcid":false,"given":"George Mathew","family":"Panachiyil","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-5611","authenticated-orcid":false,"given":"Tirin","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juny","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandyam Dhati","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"bibr1-08971900211038301","unstructured":"Deferasirox. Lexi-Drugs [online Database]. Hudson, OH: Wolters Kluwer Health; updated April 4, 2019. 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