{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:55:57Z","timestamp":1777859757723,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Introduction: Although there is evidence describing the immunomodulatory effects of macrolide antibiotics, there is little literature exploring the clinical effects these properties may have and their impact on measurable outcomes. Objective: The purpose of this study was to determine if empiric antimicrobial regimens containing azithromycin shorten time to shock resolution. Methods: A retrospective study was performed in adults with septic shock admitted to intensive care units (ICUs) of 3 university-affiliated, urban teaching hospitals between June 2012 and June 2016. Eligible patients with septic shock required treatment with norepinephrine as the first-line vasopressor for a minimum of 4\u00a0hours and received at least 48\u00a0hours of antimicrobial treatment from the time of shock onset. Propensity scores were utilized to match patients who received azithromycin to those who did not. Results: A total of 3116 patients met initial inclusion criteria. After propensity score matching, 258 patients were included, with 124 and 134 patients in the azithromycin and control groups, respectively. Median shock duration was similar in patients treated with or without azithromycin (45.6\u00a0hr vs 59.7\u00a0hr, P = .44). In-hospital mortality was also similar (37.9% vs 38.1%, P = .979). There were no significant differences in mechanical ventilation duration, ICU length of stay (LOS), or hospital LOS. Conclusions: In patients admitted to the ICU with septic shock, empiric azithromycin did not have a significant effect on shock duration, mechanical ventilation duration, ICU LOS, hospital LOS, or in-hospital mortality.<\/jats:p>","DOI":"10.1177\/08971900211064193","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T05:33:40Z","timestamp":1640842420000},"page":"559-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Azithromycin and Septic Shock Outcomes"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-8344","authenticated-orcid":false,"given":"Joseph M.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond J.","family":"Yost","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Detroit Receiving Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Pangrazzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Detroit Receiving Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katri A.","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Detroit Receiving Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman O.","family":"Soubani","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Harper University Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista A.","family":"Wahby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Harper University Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"bibr1-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.01.010"},{"key":"bibr2-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.11.001"},{"key":"bibr3-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1043"},{"key":"bibr4-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"bibr5-08971900211064193","volume-title":"[Package Insert]","author":"Zithromax R","year":"2013"},{"key":"bibr6-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1285677"},{"key":"bibr7-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.03.008"},{"key":"bibr8-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.12.010"},{"key":"bibr9-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1730-y"},{"key":"bibr10-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054108"},{"key":"bibr11-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"bibr12-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"bibr13-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"bibr14-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0352"},{"key":"bibr15-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60446-1"},{"key":"bibr16-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0921-x"},{"key":"bibr17-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202290"},{"key":"bibr18-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071366"},{"key":"bibr19-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000330"},{"key":"bibr20-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1912OC"},{"key":"bibr22-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21977"},{"key":"bibr23-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0062"},{"key":"bibr24-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2013.06.011"},{"key":"bibr25-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.12.011"},{"key":"bibr26-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138150"},{"key":"bibr27-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3822-1"},{"key":"bibr28-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819def97"},{"key":"bibr29-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20328"},{"key":"bibr30-08971900211064193","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900211064193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900211064193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900211064193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:05Z","timestamp":1777509425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900211064193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/08971900211064193"],"URL":"https:\/\/doi.org\/10.1177\/08971900211064193","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}