{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:55:58Z","timestamp":1777859758064,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>This is a case report of a 55-year-old Caucasian male prescribed topical testosterone therapy for 12\u00a0months prior to admission, when he was diagnosed with acute thrombosis in the portal vein (PVT) and superior mesenteric vein (SMV). The patient had a negative thrombophilia workup, including Factor V Leiden, Prothrombin G20210A, and JAK2 V617F mutations. There were no other pertinent laboratory markers that raised concern for the cause of thrombus. No strong familial history of venous thromboembolism (VTE) was reported during the patient\u2019s initial workup. With this in mind, the patient\u2019s use of topical testosterone therapy was considered the most likely risk factor for the PVT and SMV thrombus. During hospitalization, the patient was initiated on therapeutic anticoagulation with a heparin drip and discharged to home on apixaban for 3\u00a0months with extended therapy to be determined by outpatient hematologist. With no other identified VTE risk factors, probability that this patient\u2019s VTE was attributed to testosterone was evaluated using the Naranjo scale with a calculated score of 6, which classifies the adverse reaction as \u201clikely.\u201d Clinicians should be aware of the possibility that topical testosterone therapy may be a risk factor for venous thrombosis in unusual sites.<\/jats:p>","DOI":"10.1177\/08971900211073286","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T05:29:22Z","timestamp":1641533362000},"page":"988-992","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Portal and Superior Mesenteric Vein Thrombosis with Topical Testosterone Therapy: An Adverse Drug Event Case Report"],"prefix":"10.1177","volume":"36","author":[{"given":"Megan R.","family":"Adams","sequence":"first","affiliation":[{"name":"University of Kentucky College of Pharmacy, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-1506","authenticated-orcid":false,"given":"Kyle D.","family":"Pijut","sequence":"additional","affiliation":[{"name":"University of Kentucky Healthcare Albert B. Chandler Hospital, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey C.","family":"Uttal-Veroff","sequence":"additional","affiliation":[{"name":"University of Kentucky Healthcare Albert B. Chandler Hospital, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Pharmacy, Lexington, KY, USA"},{"name":"University of Kentucky Healthcare Albert B. Chandler Hospital, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"bibr1-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00229"},{"key":"bibr2-08971900211073286","volume-title":"Drug Safety Communications: FDA Evaluating Risk of Stroke, Heart Attack and Death with FDA-Approved Testosterone Products (January 2014)","author":"Food and Drug Administration"},{"key":"bibr3-08971900211073286","doi-asserted-by":"publisher","DOI":"10.7326\/M19-0830"},{"key":"bibr4-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2017-000637"},{"key":"bibr5-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.10.023"},{"key":"bibr6-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1002\/smrj.43"},{"key":"bibr7-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.12.029"},{"key":"bibr8-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.5135"},{"key":"bibr9-08971900211073286","volume-title":"Androgel Package Insert","author":"Food and Drug Administration"},{"key":"bibr10-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13177"},{"key":"bibr11-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1308-1"},{"key":"bibr12-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.11.026"},{"key":"bibr13-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705454"},{"key":"bibr14-08971900211073286","first-page":"e1823","volume":"9","author":"Amjad W","year":"2017","journal-title":"Cureus"},{"key":"bibr15-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.12.018"},{"key":"bibr16-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206023"},{"key":"bibr17-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02805-6"},{"key":"bibr18-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03655.x"},{"key":"bibr19-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr20-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X15611224"},{"key":"bibr21-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2301"},{"key":"bibr22-08971900211073286","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.10.007"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900211073286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900211073286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900211073286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:07Z","timestamp":1777509427000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900211073286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/08971900211073286"],"URL":"https:\/\/doi.org\/10.1177\/08971900211073286","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]}}}