{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:31Z","timestamp":1777859791210,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Background<\/jats:p>\n                  <jats:p>Storage pool deficiency (SPD) is a rare bleeding disorder characterized by reduction in the number of delta granules within platelets, interfering with hemostasis. Current literature lacks well-designed studies from which to draw concrete conclusions regarding pre-procedural management of bleeding complications. Objective: The purpose of this study is to describe bleeding and safety outcomes of SPD patients receiving either pre-procedural platelet transfusions or platelet-sparing regimens. Methods: An exploratory retrospective cohort study was conducted among SPD patients, comparing major bleeding events between those who received platelet transfusion and those who received desmopressin, tranexamic acid, and\/or aminocaproic acid within 24\u00a0hours prior to procedure. Results: Rates of major bleeding were not found to be higher among patients who received a platelet-sparing regimen [platelet-sparing: 2\/25 (8%); platelet transfusion: 2\/29 (6.9%); P = .99]. Incidence of non-major bleeding was higher in the platelet transfusion group, but this was not statistically significant [platelet-sparing: 0\/25 (0%); platelet transfusion: 3\/29 (10.3%); P = .24]. Treatment-related adverse effects were observed following 8 of 54 procedures (14.8%). Conclusion: Use of a platelet-sparing regimen was not associated with a significantly higher incidence of major or non-major bleeding events. Future prospective trials are recommended to compare outcomes between therapies.<\/jats:p>","DOI":"10.1177\/08971900221119167","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T12:23:50Z","timestamp":1660739030000},"page":"1412-1418","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Experience With Pre-procedural Hemostatic Medications versus Platelet Transfusion in Patients With Platelet Storage Pool Deficiency"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-7627","authenticated-orcid":false,"given":"Katharine A.","family":"Lundy","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Rabatin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica R.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junan","family":"Li","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Pharmacy, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa J.","family":"Snider","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric H.","family":"Kraut","sequence":"additional","affiliation":[{"name":"Division of Hematology & Oncology, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"bibr1-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01270.x"},{"key":"bibr2-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02495.x"},{"key":"bibr3-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199808000-00002"},{"key":"bibr4-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01898.x"},{"key":"bibr5-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06343.x"},{"key":"bibr6-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02842.x"},{"key":"bibr7-08971900221119167","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-1-65"},{"key":"bibr8-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90041-L"},{"key":"bibr9-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830300307"},{"key":"bibr10-08971900221119167","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328349a2a4"},{"key":"bibr11-08971900221119167","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2011.638090"},{"key":"bibr12-08971900221119167","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082508"},{"key":"bibr13-08971900221119167","unstructured":"Lexicomp [Internet]. Hudson (OH): Wolters Kluwer Clinical Drug Information, Inc. 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