{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:03:58Z","timestamp":1783350238281,"version":"3.54.6"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Purpose: A case of sulfamethoxazole\/trimethoprim-induced agranulocytosis is reported. Summary: A 53-year-old healthy male presented to the emergency room with a fever of 102.7\u00b0F and was found to have a white blood cell (WBC) count of 0.6 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    cells\/\u03bcL with an absolute neutrophil count (ANC) of 0.0 x 10\n                    <jats:sup>3<\/jats:sup>\n                    cells\/\u03bcL. He had recently completed a 10-day course of sulfamethoxazole\/trimethoprim for left lower extremity cellulitis. During admission, a bone marrow biopsy was performed which was not concerning for malignancy and no cause for the agranulocytosis other than the sulfamethoxazole\/trimethoprim was identified. The agranulocytosis resolved after 6\u00a0days of hospitalization with a WBC count of 8.9 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    cells\/\u03bcL and an ANC of 4.1 x 10\n                    <jats:sup>3<\/jats:sup>\n                    cells\/\u03bcL on the day of discharge. Conclusion: A 53-year-old male developed agranulocytosis after 10\u00a0days of sulfamethoxazole\/trimethoprim therapy for the treatment of a skin and soft tissue infection. His neutropenia resolved after sulfamethoxazole\/trimethoprim discontinuation.\n                  <\/jats:p>","DOI":"10.1177\/08971900221128854","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T07:17:18Z","timestamp":1664263038000},"page":"229-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Agranulocytosis Associated With Use of Sulfamethoxazole\/Trimethoprim in a Healthy Adult"],"prefix":"10.1177","volume":"37","author":[{"given":"David","family":"Bunch","sequence":"first","affiliation":[{"name":"Department of Pharmacy, M Health Fairview, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Brands","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, M Health Fairview, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-2497","authenticated-orcid":false,"given":"Diana R.","family":"Langworthy","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, M Health Fairview, Minneapolis, MN, USA"},{"name":"Department of Pharmaceutical Care and Health Systems, University of Minnesota College of Pharmacy, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"bibr1-08971900221128854","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-103"},{"key":"bibr2-08971900221128854","first-page":"1083","volume-title":"Goldman\u2019s Cecil Medicine","author":"Goldman L","year":"2011","edition":"24"},{"key":"bibr3-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr4-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.187"},{"key":"bibr5-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00072-9"},{"key":"bibr6-08971900221128854","first-page":"323","volume":"228","author":"Keisu M","year":"1009","journal-title":"J Intern Med"},{"key":"bibr7-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1997.00590.x"},{"key":"bibr8-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1177\/135965350501000510"},{"key":"bibr9-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1111\/all.13765"},{"key":"bibr10-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001118"},{"key":"bibr11-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5653497"},{"key":"bibr12-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5782.301-b"},{"key":"bibr13-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5643.578"},{"key":"bibr14-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.05.008"},{"key":"bibr15-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1998.tb03158.x"},{"key":"bibr16-08971900221128854","first-page":"19","volume":"85","author":"Harris GJ","year":"1986","journal-title":"Wis Med J"},{"key":"bibr17-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1998.00008.x"},{"key":"bibr18-08971900221128854","first-page":"433","volume":"78","author":"Casey TP","year":"1973","journal-title":"N Z Med J"},{"key":"bibr19-08971900221128854","doi-asserted-by":"publisher","DOI":"10.12890\/2021_002215"},{"key":"bibr20-08971900221128854","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.1.90"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900221128854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900221128854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900221128854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:51Z","timestamp":1777509471000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900221128854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/08971900221128854"],"URL":"https:\/\/doi.org\/10.1177\/08971900221128854","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]}}}