{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:38Z","timestamp":1777859798295,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    The objective of this study is to characterize opioid intensity in the intensive care unit (ICU) and its association with opioid utilization across care transitions.\n                    <jats:bold>Methods:<\/jats:bold>\n                    This is a prospective cohort study. Medically ill ICU patients with complete medication histories who survived to discharge were included. Opioid intensity was characterized based on IV morphine milligram equivalents (IV MME). Primary outcomes were opioid prescribing upon ICU and hospital discharge.\n                    <jats:bold>Results:<\/jats:bold>\n                    Opioids were prescribed to 34.1% and 31.1% of patients upon ICU and hospital discharge. Within the \u226550 mean IV MME\/ICU day cohort, 64.7% of patients received opioids after ICU discharge compared to 45.8% and 13.6% in the 1-49 mean IV MME\/ICU day and no opioid groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Within the \u226550 mean IV MME\/ICU day cohort, 70.6% of patients were prescribed opioids after hospitalization compared to 37.3% and 13.6% of patients who received less or no opioids. (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Within the \u226550 mean IV MME\/ICU day cohort, 29.4% of patients were opioid na\u00efve and discharged with an opioid, which is over double compared to patients with lower opioid requirements (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Patients with higher mean daily ICU opioid requirements had increased opioid prescribing across care transitions despite preadmission opioid use.\n                  <\/jats:p>","DOI":"10.1177\/08971900221134553","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T06:44:12Z","timestamp":1666161852000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Opioid Use in the Intensive Care Unit and Its Impact Across Care Transitions: A Prospective Study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-1615","authenticated-orcid":false,"given":"Christian D.","family":"Hauser","sequence":"first","affiliation":[{"name":"Critical Care and Emergency Medicine Clinical Pharmacy Specialist, Department of Pharmacy, Indiana University Health Methodist Hospital, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-9934","authenticated-orcid":false,"given":"Carolyn M.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-2874","authenticated-orcid":false,"given":"R. Amanda","family":"Zamora","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Washington DC VA Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9752-2654","authenticated-orcid":false,"given":"Ron R.","family":"Neyens","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.04.025"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003299"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182783b72"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-36"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00023"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199804000-00011"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.2737"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-015-3539-4"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/M18-2864"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066615618189"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201912-2503OC"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003358"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_4_15_2","first-page":"716","article-title":"Implications of the opioid epidemic for critical care practice","volume":"53","author":"Erstad BL","year":"2019","unstructured":"Erstad BL. 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