{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:48Z","timestamp":1777859808149,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Background: Tocilizumab and baricitinib have emerged as potential treatments for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following the findings of the Recovery Group and the results of the COV-BARRIER study. Unfortunately, there is a lack of guidance regarding the use of these agents in high-risk patients, such as those with obesity. Objective: To compare the outcomes of tocilizumab and baricitinib as potential treatments for obese patients infected with SARS-CoV-2. Methods: This was a multi-center retrospective analysis comparing outcomes of obese patients who received the standard of care plus tocilizumab or baricitinib for the treatment of SARS-CoV-2. Included patients had a BMI &gt;30\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , needed ICU level care, and required non-invasive or invasive ventilatory support. Results: This study included 64 patients who received tocilizumab and 69 patients who received baricitinib. When examining the primary outcome, patients who received tocilizumab had a shorter duration of ventilatory support (10.0 vs 15.0 days, P = .016) than patients who received baricitinib. Our secondary outcome of in-hospital mortality was lower in the tocilizumab group as well (23.4% vs 53.6%, P &lt; .001). Tocilizumab was also associated with a non-significant reduction in new positive blood cultures (13.0% vs 3.1%, P = .056) and new invasive fungal infection (7.3% vs 1.6%, P = .210). Conclusions: This retrospective review showed a reduced duration of ventilatory support in obese patients who received tocilizumab vs baricitinib. In the future, additional studies should be conducted to further examine and confirm these results.\n                  <\/jats:p>","DOI":"10.1177\/08971900231158931","type":"journal-article","created":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T20:25:21Z","timestamp":1676838321000},"page":"632-636","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Tocilizumab Versus Baricitinib for the Treatment of COVID-19 in Patients With Obesity"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-086X","authenticated-orcid":false,"given":"Bradley S.","family":"Troyer","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, University of Charleston School of Pharmacy, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Kovacic Scherrer","sequence":"additional","affiliation":[{"name":"Critical Care Pharmacy Department, West Virginia University Hospitals, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Garavaglia","sequence":"additional","affiliation":[{"name":"Critical Care Pharmacy Department, West Virginia University Hospitals, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"bibr1-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028700"},{"key":"bibr2-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030340"},{"key":"bibr3-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00676-0"},{"key":"bibr4-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00331-3"},{"key":"bibr5-08971900231158931","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7010e4"},{"key":"bibr6-08971900231158931","unstructured":"America's Health Rankings: United Health Foundation. Americashealthrankings.org. Published December. 2021. Accessed August 15, 2022. https:\/\/www.americashealthrankings.org\/explore\/annual\/measure\/Obesity."},{"key":"bibr7-08971900231158931","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58040513"},{"key":"bibr8-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000702"},{"key":"bibr9-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-020-00212"},{"issue":"2","key":"bibr10-08971900231158931","first-page":"162","volume":"93","author":"Hotoleanu C","year":"2020","journal-title":"Med Pharm Rep"},{"key":"bibr11-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07421-3"},{"key":"bibr12-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13225"},{"key":"bibr13-08971900231158931","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab726"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900231158931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900231158931","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900231158931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:05Z","timestamp":1777509485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900231158931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/08971900231158931"],"URL":"https:\/\/doi.org\/10.1177\/08971900231158931","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,19]]}}}