{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:50Z","timestamp":1777859810065,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Background: Cytomegalovirus (CMV) infection after abdominal organ transplantation is associated with increased morbidity and mortality. The use of valganciclovir for CMV prophylaxis is limited by drug-induced myelosuppression and potential emergence of resistance. Letermovir is approved for primary CMV prophylaxis in CMV seropositive allogeneic hematopoietic cell transplant recipients. However, it is increasingly used off-label for prophylaxis in solid organ transplant (SOT) recipients. Methods: Based on pharmacy records, we examined retrospectively the use of letermovir for CMV prophylaxis in abdominal transplant recipients initiated on therapy at our center from January 1, 2018 through October 15, 2020. Data were summarized using descriptive statistics. Results: Twelve episodes of letermovir prophylaxis occurred in ten patients. Four patients received primary and 6 patients received secondary prophylaxis during the study period, with 1 patient receiving letermovir secondary prophylaxis on 3 separate occasions. All patients receiving letermovir for primary prophylaxis had successful outcomes. However, letermovir secondary prophylaxis was unsuccessful in 5 of the 8 episodes (62.5%) due to breakthrough CMV DNAemia and\/or disease. Only 1 patient discontinued therapy due to adverse effects. Conclusion: Although letermovir was generally well tolerated, the high rate of failure when used as secondary prophylaxis was noteworthy. Additional controlled clinical trials assessing the safety and efficacy of letermovir prophylaxis in SOT recipients are warranted.<\/jats:p>","DOI":"10.1177\/08971900231176430","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T20:40:12Z","timestamp":1686084012000},"page":"770-779","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of Letermovir for Primary and Secondary Cytomegalovirus Prophylaxis in Abdominal Organ Transplantation: A Single Center Experience"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-1339","authenticated-orcid":false,"given":"Dima","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Burjeel Medical City, Abu Dhabi, UAE"},{"name":"Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Byrns","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7779-9605","authenticated-orcid":false,"given":"Eileen","family":"Maziarz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara D.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Saullo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"bibr1-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1086\/528718"},{"key":"bibr2-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23539"},{"key":"bibr3-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000160"},{"key":"bibr4-08971900231176430","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-12-200512200-00005"},{"key":"bibr5-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"bibr6-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000386"},{"key":"bibr7-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001338"},{"key":"bibr8-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix696"},{"key":"bibr9-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.Supplement_3.S490"},{"key":"bibr10-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13570"},{"key":"bibr11-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"bibr12-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01623-15"},{"key":"bibr13-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00922-18"},{"key":"bibr14-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13515"},{"key":"bibr15-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"bibr16-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy696"},{"key":"bibr17-08971900231176430","unstructured":"Merck & Co Inc. Dosing for PREVYMIS\n                      TM\n                      (letermovir). Accessed May 26, 2021. Available at: https:\/\/www.merckconnect.com\/prevymis\/dosing-administration\/"},{"key":"bibr18-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13166"},{"issue":"21","key":"bibr19-08971900231176430","first-page":"02626","volume":"22","author":"Saullo JL","year":"2021","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"bibr20-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13766"},{"issue":"8","key":"bibr21-08971900231176430","first-page":"2253","volume":"75","author":"Alain S","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"bibr22-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002785"},{"key":"bibr23-08971900231176430","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02337-18"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900231176430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900231176430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900231176430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:08Z","timestamp":1777509488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900231176430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/08971900231176430"],"URL":"https:\/\/doi.org\/10.1177\/08971900231176430","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]}}}