{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:50Z","timestamp":1777859810062,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["5U54GM104942-04"],"award-info":[{"award-number":["5U54GM104942-04"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Background: There is no standard approach for managing the use or dose of loop diuretics after initiating sacubitril\/valsartan. Objective: To investigate longitudinal trends in loop diuretic therapy use and doses during the initial 6\u00a0months following sacubitril\/valsartan initiation. Methods: This retrospective cohort study included adult patients who were initiated on sacubitril\/valsartan in cardiology clinics. Inclusion criteria were patients diagnosed with heart failure with reduced ejection fraction (ejection fraction \u226440%) and initiated on sacubitril\/valsartan in an outpatient setting. We investigated longitudinal trends in the prevalence of loop diuretic use and furosemide equivalent dose at baseline, 2\u00a0weeks, 1\u00a0month, 3\u00a0month and 6\u00a0months following sacubitril\/valsartan initiation. Results: A total of 427 patients were included in the final cohort. Compared to the baseline loop diuretic use and dose, there were no significant longitudinal changes in the prevalence of loop diuretic use or the furosemide equivalent dose over the 6\u00a0months following sacubitril\/valsartan initiation. The use of sacubitril\/valsartan was not significantly associated with reductions in the use or dose of loop diuretics over a 6-month follow-up period. Conclusion: The use of sacubitril\/valsartan did not significantly change the use or dose of loop diuretics over 6-month follow-up period. Initiation of sacubitril\/valsartan may not need a pre-emptive loop diuretic dose reduction.<\/jats:p>","DOI":"10.1177\/08971900231177202","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T08:33:07Z","timestamp":1684225987000},"page":"708-711","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sacubitril\/Valsartan Does Not Change the Use and Dose of Loop Diuretics in Patients With Heart Failure With Reduced Ejection Fraction"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-8025","authenticated-orcid":false,"given":"Kazuhiko","family":"Kido","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, West Virginia University School of Pharmacy, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Bianco","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, West Virginia University, Morgantown, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-0474","authenticated-orcid":false,"given":"Marco","family":"Caccamo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, West Virginia University, Morgantown, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Tokyo Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-0749","authenticated-orcid":false,"given":"Lyn Yuen","family":"Choo","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Sokos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, West Virginia University, Morgantown, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"bibr1-08971900231177202","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0b013e318291329a"},{"key":"bibr2-08971900231177202","first-page":"e895","volume":"145","author":"Heidenreich PA","year":"2022","journal-title":"Circulation"},{"key":"bibr3-08971900231177202","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"bibr4-08971900231177202","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1402"},{"key":"bibr5-08971900231177202","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1598702"},{"key":"bibr6-08971900231177202","doi-asserted-by":"publisher","DOI":"10.1177\/08971900211010680"},{"key":"bibr7-08971900231177202","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08484"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900231177202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900231177202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900231177202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:09Z","timestamp":1777509489000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900231177202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/08971900231177202"],"URL":"https:\/\/doi.org\/10.1177\/08971900231177202","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}