{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:46:20Z","timestamp":1792539980907,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Purpose: Ascorbic acid has been proposed as an alternative treatment for methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, its efficacy has never been compared to that of methylene blue given the inability of patients with G6PD deficiency to receive methylene blue. We present a case of methemoglobinemia treated with ascorbic acid in a patient without G6PD deficiency who had previously received methylene blue. Summary: A 66-year-old male was treated for methemoglobinemia deemed to be secondary to benzocaine throat spray. He received intravenous (IV) methylene blue but had a severe reaction: diaphoresis, lightheadedness, and hypotension. The infusion was stopped prior to completion. Approximately 6 days later he presented with methemoglobinemia following an additional overconsumption of benzocaine and was treated with ascorbic acid. In both instances his methemoglobin levels were &gt;30% on arterial blood gas on admission and decreased to 6.5% and 7.8%, respectively, after administration of methylene blue and ascorbic acid. Conclusion: Ascorbic acid had a similar effect on decreasing the concentration of methemoglobin compared to methylene blue. Further research into use of ascorbic acid as a recommended agent for treatment of methemoglobinemia is warranted.<\/jats:p>","DOI":"10.1177\/08971900231188834","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T11:40:11Z","timestamp":1688816411000},"page":"1015-1020","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Ascorbic Acid for Methemoglobinemia Treatment: A Case Report and Literature Review"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-1079","authenticated-orcid":false,"given":"Kelli R","family":"Keats","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,8]]},"reference":[{"key":"bibr1-08971900231188834","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26340"},{"key":"bibr2-08971900231188834","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.02910300061020"},{"key":"bibr3-08971900231188834","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"bibr4-08971900231188834","unstructured":"Methylene Blue [Internet]. 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