{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:04Z","timestamp":1777859824737,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Pregabalin is an anti-epileptic drug approved for the treatment of neuropathic pain and focal-onset seizures. In a few cases, pregabalin was associated with parkinsonism. We present a case of a 48-year-old female who had hypertension and was on losartan 50\u00a0mg\/daily. Her general practitioner prescribed pregabalin 150\u00a0mg\/daily for fibromyalgia-related pain. The subject doubled the dosage without medical advice. After 5 days of the increased dosage, she started to experience difficulty and slowness in movement associated with resting tremors. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable. Secondary parkinsonism was suspected, so pregabalin was discontinued. The subject fully recovered within 7\u00a0days. To the authors\u2019 knowledge, only 6 cases of pregabalin-induced parkinsonism were reported in the literature. Pregabalin discontinuation was the most common management. All individuals fully recovered after pregabalin withdrawal. The mechanism of pregabalin-induced parkinsonism is not fully understood.<\/jats:p>","DOI":"10.1177\/08971900241247119","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T23:48:00Z","timestamp":1712879280000},"page":"1220-1224","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pregabalin-Induced Parkinsonism: Case Report and Review of the Literature"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-5911","authenticated-orcid":false,"given":"Hossam Tharwat","family":"Ali","sequence":"first","affiliation":[{"name":"Qena Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Abdelhameed","family":"Khalil","sequence":"additional","affiliation":[{"name":"Qena Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Leticia Fornari","family":"Caprara","sequence":"additional","affiliation":[{"name":"Medicine Department, Federal University of Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamir Pitton","family":"Rissardo","sequence":"additional","affiliation":[{"name":"Medicine Department, Federal University of Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"bibr1-08971900241247119","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_57_19"},{"key":"bibr2-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.09.008"},{"key":"bibr3-08971900241247119","volume-title":"StatPearls","author":"Cross AL","year":"2023"},{"key":"bibr4-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007076.pub3"},{"key":"bibr5-08971900241247119","doi-asserted-by":"publisher","DOI":"10.2174\/0115748863290330240116094015"},{"key":"bibr6-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1177\/19418744231173283"},{"key":"bibr7-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000565"},{"key":"bibr8-08971900241247119","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.304071"},{"key":"bibr9-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2016.09.001"},{"issue":"3","key":"bibr10-08971900241247119","first-page":"E349","volume":"15","author":"Matsuki Y","year":"2012","journal-title":"Pain Physician"},{"key":"bibr11-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181a9eb1b"},{"key":"bibr12-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1002\/jppr.1363"},{"key":"bibr13-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1496"},{"key":"bibr14-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1177\/2042098613505614"},{"key":"bibr15-08971900241247119","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1072629"},{"key":"bibr16-08971900241247119","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS8080872"},{"key":"bibr17-08971900241247119","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27876"},{"key":"bibr18-08971900241247119","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v24i1.25"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900241247119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900241247119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900241247119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:26Z","timestamp":1777509506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900241247119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/08971900241247119"],"URL":"https:\/\/doi.org\/10.1177\/08971900241247119","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]}}}