{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:39:08Z","timestamp":1790797148840,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Bruton\u2019s tyrosine kinase inhibitors (BTKis) are the preferred treatment for chronic lymphocytic leukemia (CLL). Despite their therapeutic benefits, these targeted agents have been associated with an increased risk of invasive infections. We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with Cryptococcus neoformans and Aspergillus fumigatus, along with cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) pneumonia while on acalabrutinib. This case adds to the scarce literature of fungal and bacterial infections associated with acalabrutinib, raising the suspicion that infection risk is a medication class effect for BTKis.<\/jats:p>","DOI":"10.1177\/08971900241247660","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T19:51:15Z","timestamp":1713210675000},"page":"1391-1395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib"],"prefix":"10.1177","volume":"37","author":[{"given":"Taylor","family":"Fallin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences, OU Health, University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences, OU Health, University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda","family":"Sahra","sequence":"additional","affiliation":[{"name":"Infectious Diseases Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Siegrist","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Clinical Infectious Diseases, OU Health, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-7069","authenticated-orcid":false,"given":"Bryan P.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Clinical Infectious Diseases, OU Health, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Critical Care, OU Health, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena","family":"Shibib","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Virology Laboratories, OU Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sassine","sequence":"additional","affiliation":[{"name":"Infectious Diseases Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"bibr1-08971900241247660","author":"Wierda WG","journal-title":"J Natl Compr Canc Netw"},{"key":"bibr2-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-0715-5"},{"key":"bibr3-08971900241247660","doi-asserted-by":"publisher","DOI":"10.3390\/jof7121058"},{"key":"bibr4-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-567388"},{"key":"bibr5-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0575-9"},{"key":"bibr6-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17732"},{"key":"bibr7-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1775215"},{"key":"bibr8-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.04.012"},{"key":"bibr9-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01210"},{"key":"bibr10-08971900241247660","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28010081"},{"key":"bibr11-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0000000000000722"},{"key":"bibr12-08971900241247660","first-page":"S165","volume":"70","author":"Carlson L","year":"2022","journal-title":"Epidemiology"},{"key":"bibr13-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012612"},{"key":"bibr14-08971900241247660","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8888270"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900241247660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900241247660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900241247660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:27Z","timestamp":1777509507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900241247660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/08971900241247660"],"URL":"https:\/\/doi.org\/10.1177\/08971900241247660","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]}}}