{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:52:57Z","timestamp":1777859577025,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Objective: We evaluated the impact of a methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) protocol on the vancomycin length of therapy (LOT) for skin and soft tissue infections (SSTIs). Design: Retrospective quasi-experimental pre- and post- MRSA nasal PCR protocol implementation study. Setting: Tertiary-care academic medical center in Jacksonville, Florida. Patients: Eligible patients received empiric vancomycin for SSTIs from January 1st to September 30th 2020 (pre-implementation group) and from January 1st to September 30th 2022 (post-implementation group). Intervention: The electronic health system software was modified to provide a best-practice advisory (BPA) prompt to the pharmacist upon order verification of vancomycin for patients with SSTIs. Methods: We reviewed patient records to determine the time from vancomycin prescription to de-escalation. The secondary outcomes were incidence of acute kidney injury (AKI), number of vancomycin levels collected, and hospital length of stay (LOS). Results: The study included 131 patients (pre-implementation, n = 86 and post-implementation, n = 45). There was no significant difference in vancomycin length of therapy (LOT) between implementation groups: mean LOT in days and standard deviation (SD) were 2.7 (1.9) and 2.6 (1.3), respectively, p-value 0.493. Of significance, in the post-implementation group, vancomycin LOT between patients with a negative and positive MRSA PCR were 2.3 (1.1) and 3.9 (1.6), p-value 0.006. There was no difference in secondary outcomes. Conclusion: The utilization of the MRSA nasal PCR to guide vancomycin de-escalation did not significantly change the vancomycin LOT, however in the post-implementation group there was a significant difference in vancomycin LOT between negative and positive MRSA PCRs.<\/jats:p>","DOI":"10.1177\/08971900241273175","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:30:06Z","timestamp":1723249806000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of a Methicillin-Resistant Staphylococcus Aureus Nasal Polymerase Chain Reaction Protocol on Vancomycin Length of Therapy Among Patients With Skin and Soft Tissue Infections"],"prefix":"10.1177","volume":"38","author":[{"given":"Anel","family":"Couzo","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adia","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6275-8604","authenticated-orcid":false,"given":"Courtney M.","family":"Willis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Mendez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-233X","authenticated-orcid":false,"given":"Kevin L.","family":"Epps","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"bibr1-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu444"},{"key":"bibr2-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1086\/502591"},{"key":"bibr3-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1086\/422997"},{"key":"bibr4-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2021.12.005"},{"key":"bibr5-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2020.345"},{"key":"bibr6-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz974"},{"key":"bibr7-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1177\/10600280221127389"},{"key":"bibr8-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2020-0125"},{"key":"bibr9-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002743"},{"key":"bibr10-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"bibr11-08971900241273175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900241273175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900241273175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900241273175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:36Z","timestamp":1777509216000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900241273175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/08971900241273175"],"URL":"https:\/\/doi.org\/10.1177\/08971900241273175","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]}}}