{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:53:04Z","timestamp":1777859584709,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Necrotizing fasciitis is a serious infection that requires prompt surgical excision and broad spectrum antibiotics. Fournier\u2019s gangrene (FG) is a type of necrotizing fasciitis that specifically affects the perineal, scrotal, and genital region. FG is a known adverse outcome of the class of medications known as sodium-glucose cotransporter 2 (SGLT2) inhibitors. This class of drugs is most commonly use to treat diabetes, but recently it\u2019s use has expanded to include those with heart failure, regardless of whether they have diabetes. With the increased use of SGLT2 inhibitors, the incidence of FG may increase as well. We present 2 case reports of patients who experienced FG while on SGLT2 inhibitor therapy.<\/jats:p>","DOI":"10.1177\/08971900241302881","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T01:05:17Z","timestamp":1732151117000},"page":"410-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fournier\u2019s Gangrene and Sodium-Glucose Cotransporter 2 Inhibitor Use: A Report of Two Cases"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-3918","authenticated-orcid":false,"given":"Zane","family":"Elfessi","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA"},{"name":"College of Pharmacy, Department of Pharmacy Practice, University of Illinois-Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Portnoy","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Karydes","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Zavala","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu296"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/TME.0000000000000221"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.12.041"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14031"},{"issue":"4","key":"e_1_3_4_6_2","first-page":"283","article-title":"Impact of immunodeficiency virus (HIV) on Fournier's gangrene: observations in Zambia","volume":"77","author":"Elem B","year":"1995","unstructured":"Elem B, Ranjan P. 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