{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:53:09Z","timestamp":1777859589150,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Inclusion of numeric, actionable renal dosing recommendations in drug information resources enhances the safe use of nephrotoxins.\n                    <jats:bold>Purpose:<\/jats:bold>\n                    The purpose of this study was to systematically and descriptively characterize the renal dose recommendations for nephrotoxic medications in 4 common drug information resources.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A list of nephrotoxins (N = 154) was generated from previously published lists. Renal dosing information was collected for each drug from the package insert, Lexi-comp (now called UpToDate Lexidrug), Micromedex, and Clinical Pharmacology. Dosing recommendations were categorized using a previously published 6-category scale based on whether recommendations were included vs missing, and numeric vs non-numeric.\n                    <jats:bold>Results:<\/jats:bold>\n                    Actionable renal impairment recommendations (numeric, non-numeric, contraindicated, no dose adjustment required) in the package insert, Lexi-comp, Micromedex, and Clinical Pharmacology were present for 88.3%, 98.1%, 94.2%, and 98.1% of drugs, respectively. Numeric recommendations were available for 54.5% to 75.3% of medications, depending on the source. Actionable recommendations for hemodialysis, peritoneal dialysis, continuous renal replacement, and hybrid dialysis modalities were more common in Lexi-comp (83.1%, 75.3%, 62.3%, and 53.9% of medications, respectively) vs the other resources. Actionable pediatric renal impairment (76.0%) and older adult (95.5%) recommendations were also more common in Lexi-comp than other resources.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Drug information resources included actionable renal dosing recommendations for most known nephrotoxins, with Lexi-comp being most likely to include this information. Numeric and\/or actionable recommendations for specific dosing populations (eg, renal replacement modalities, pediatric renal impairment, older adults) were generally lacking. Lack of agreement among resources suggests a need to check multiple sources in practice.\n                  <\/jats:p>","DOI":"10.1177\/08971900251364049","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T12:23:49Z","timestamp":1753705429000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Actionable Renal Dosing Content for Nephrotoxic Medications in 4 Drug Information Resources Commonly Used in the United States"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-1358","authenticated-orcid":false,"given":"Heather","family":"Ipema","sequence":"first","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Maslennikov","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy (formerly)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-498X","authenticated-orcid":false,"given":"Faria","family":"Munir","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Hartke","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruba","family":"Alomari","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy (formerly)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dazy","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy (formerly)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Wierzbiak","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Retzky College of Pharmacy (formerly)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2020.11.002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa022"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120911227"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12291"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38476.471088.3A"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-022-01173-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxz203"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019897371"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/10600280241273191"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900251364049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900251364049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900251364049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:51Z","timestamp":1777509231000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900251364049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/08971900251364049"],"URL":"https:\/\/doi.org\/10.1177\/08971900251364049","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}