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IPA is readily absorbed through intact skin and metabolized to acetone, which may exert neurotoxic effects. Chronic dermal exposure can lead to peripheral nerve damage via oxidative stress, mitochondrial dysfunction, and local inflammation. We report an 80-year-old male who developed left lower extremity numbness following topical application of IPA multiple times daily for 3\u00a0months for pain relief. After differential diagnoses were ruled out, cessation of the IPA led to complete resolution after 3\u00a0weeks.<\/jats:p>","DOI":"10.1177\/08971900261416821","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:27:57Z","timestamp":1768202877000},"page":"472-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isopropyl Alcohol-Induced Peripheral Neuropathy After Transdermal Exposure: A Case Report"],"prefix":"10.1177","volume":"39","author":[{"given":"Jack","family":"Shapiro","sequence":"first","affiliation":[{"name":"Northwestern Medicine Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cranmer","sequence":"additional","affiliation":[{"name":"Jesse Brown Veterans Affairs Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Formaro","sequence":"additional","affiliation":[{"name":"University of Illinois-Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Herrera","sequence":"additional","affiliation":[{"name":"University of Illinois-Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-3918","authenticated-orcid":false,"given":"Zane","family":"Elfessi","sequence":"additional","affiliation":[{"name":"Jesse Brown Veterans Affairs Medical Center"},{"name":"University of Illinois-Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"CDC. Nerve Damage. Centers for Disease Control and Prevention. 2024. https:\/\/www.cdc.gov\/diabetes\/diabetes-complications\/diabetes-and-nerve-damage.html. Accessed August 12 2025."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1212-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7335.466"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_3_6_2","volume-title":"Statpearls [Internet] Treasure Island (FL)","author":"Ashurst JV","year":"2021","unstructured":"Ashurst JV, Nappe TM. Statpearls [Internet] Treasure Island (FL). StatPearls Publishing; 2021."},{"key":"e_1_3_3_7_2","first-page":"PMC8689373","volume":"2021","author":"Sadowski A","unstructured":"Sadowski A, Houck RC. 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