{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:28:08Z","timestamp":1787300888446,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Permanente Medical Group\u2019s Delivery Science and Applied Research Program"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Bone-health risk assessment and treatment among prostate-cancer patients on androgen-deprivation therapy (ADT) is often inadequately completed in clinical practice.\n                    <jats:bold>Objective:<\/jats:bold>\n                    To determine the impact of a population-management program on bone-health risk assessment and bisphosphonate therapy among prostate-cancer patients on ADT.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We used retrospective data from a large integrated healthcare system to identify men aged 41-89\u00a0years diagnosed with prostate cancer in 2011-2024 who received \u22651 ADT dose. We compared adherence to internal guideline-recommended bone mineral density (BMD) testing, laboratory evaluation, and bisphosphonate prescriptions at baseline and during follow-up between men enrolled in the population-health program with men and men who were not enrolled (non-enrolled).\n                    <jats:bold>Results:<\/jats:bold>\n                    Among the 9934 eligible patients, 1680 (17%) were enrolled in the program and 8254 (83%) were non-enrolled. The proportion of enrolled patients completing BMD scans within 1 year before or after ADT initiation (80.6%) was substantially higher than among non-enrolled patients (23.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001). More enrolled patients were treated with antiresorptive therapy (26.4%) than among non-enrolled patients (14.1%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001). Overall, enrollees were more likely to have ever received any guideline-indicated intervention (78.7% vs 27.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001). The average coverage percentage for BMD screening was 24.4% among non-enrolled patients vs 81.1% among enrolled patients (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001). Among antiresorptive-treatment-eligible patients, the average coverage percentage for bisphosphonate therapy was 35.5% among non-enrolled patients compared with 46.1% among enrolled patients (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The population-management program significantly outperformed usual care in adherence to BMD testing, laboratory evaluation, and indicated antiresorptive osteoporosis-medication treatment among men with prostate cancer on ADT.\n                  <\/jats:p>","DOI":"10.1177\/08971900261478840","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:19:26Z","timestamp":1787116766000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Standardized Bone Health Assessment and Treatment Among Prostate Cancer Patients on Androgen Deprivation Therapy in a Large Integrated Managed Care Delivery System"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3737-6667","authenticated-orcid":false,"given":"Michael J.","family":"Shulman","sequence":"first","affiliation":[{"name":"Kaiser Permanente Roseville Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon H.","family":"Horton","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-0648","authenticated-orcid":false,"given":"Joan C.","family":"Lo","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J.","family":"Meganck","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masy K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Park-Sigal","sequence":"additional","affiliation":[{"name":"Kaiser Permanente South San Francisco Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-7904","authenticated-orcid":false,"given":"Andrew L.","family":"Avins","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03148"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0050"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0083-z"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0183"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0902"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041943"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2258"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3135-9"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.652979"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2168"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00033-9"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11758.x"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64561-2"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06542-4"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.0070"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27830"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2997-6"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.5432"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/UPJ.0000000000000473"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.01.054"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31171"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00093.x"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.11.066"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/15-225"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/22.172"},{"key":"e_1_3_7_27_2","unstructured":"Home | FRAXplus\u00ae [Internet]. 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