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Article nominations included those pertaining to general ID and human immunodeficiency virus\/acquired immunodeficiency syndrome (HIV\/AIDS) pharmacotherapy. To aid selection of the most notable articles of 2025, a survey was created and distributed to members of the Society of Infectious Diseases Pharmacists (SIDP). A total of 32 articles were nominated by HIDN\/SIDP members, 26 articles related to general ID pharmacotherapy and 6 articles focusing on HIV\/AIDS. Of the 212 SIDP members who participated in the survey, there were 101 recorded votes for the top 10 general ID pharmacotherapy articles and 40 votes recorded for the top HIV\/AIDS article. The most notable publications are summarized. Ongoing research continues to discover findings that enhance antimicrobial stewardship and inform best practices in infectious diseases. From over 2000 articles published on PubMed using the keywords \u201cinfectious diseases,\u201d \u201cHIV,\u201d \u201cpharmacotherapy,\u201d and \u201canti-infective,\u201d this review highlights and summarizes the most influential ID publications with aims to update clinicians on potentially practice-changing ID pharmacotherapy publications from 2025.<\/jats:p>","DOI":"10.1177\/08971900261486586","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:26:57Z","timestamp":1789601217000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Significant Publications on Infectious Diseases Pharmacotherapy in 2025"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1826-6715","authenticated-orcid":false,"given":"Vy N.","family":"Quach","sequence":"first","affiliation":[{"name":"Baylor St. Luke\u2019s Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2130-8858","authenticated-orcid":false,"given":"Khadija","family":"Thomas","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-2127","authenticated-orcid":false,"given":"Kevin","family":"Lin","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy P.","family":"Su","sequence":"additional","affiliation":[{"name":"Houston Methodist West Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Al Shaikhli","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adenike","family":"Olabode","sequence":"additional","affiliation":[{"name":"Memorial Hermann The Woodlands Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-9897","authenticated-orcid":false,"given":"Nancy N.","family":"Vuong","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-3267","authenticated-orcid":false,"given":"Nhi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Harris Health Ben Taub Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080182"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp090099"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100090"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110125"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120151"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp130129"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp140148"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150112"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160090"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190017727212"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190018792797"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190019863921"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190020951348"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/08971900211040438"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/08971900221128334"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/08971900231194200"},{"key":"e_1_3_3_18_2","first-page":"897190025131881","article-title":"Significant publications on infectious diseases pharmacotherapy in 2023","volume":"6","author":"Stabler AV","year":"2025","unstructured":"Stabler AV, Huynh-Phan R, Amin K, et al. 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