{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:10:49Z","timestamp":1788667849561,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Mayo Midwest Pharmacy Research Committee"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Practice"],"abstract":"<jats:p>\n                    Prolonged durations of hypotension during septic shock promote organ injury and mortality. Empirical evidence suggests that earlier vasopressin initiation may improve outcomes in septic shock. The objective of this study was to determine the effect of a ready-to-use vasopressin formulation availability in intensive care unit automated dispensing cabinets on outcomes in septic shock. This was a pre-post quasi experimental study of adults admitted for septic shock who received vasopressin as a second line vasopressor after norepinephrine. Inverse probability of treatment weighting with propensity scores was used to balance baseline covariates between those who received the ready-to-use vasopressin product and the traditional pharmacy-compounded vasopressin product. Outcomes included time from vasopressin order to administration, time to target mean arterial pressure, length of stay, and mortality. A total of 1104 patients with septic shock were included. After propensity score adjustment, the ready-to-use group was associated with faster time to vasopressin administration (17 vs 41 min,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), faster time to target mean arterial pressure (hazard ratio 1.29, 95% CI 1.14 to 1.47,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), and a shorter length of intensive care unit stay (hazard ratio 1.23, 95% CI 1.06 to 1.43,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.006) as the compounded group. Mortality was not significantly different. In patients with septic shock, availability of a ready-to-use vasopressin product in the intensive care unit automated medication dispensing cabinet was associated with faster time to administration, improved time to target mean arterial pressure, and reduced duration of intensive care.\n                  <\/jats:p>","DOI":"10.1177\/08971900261486608","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:45:45Z","timestamp":1788500745000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Ready-To-Use Vasopressin Product Availability in Automatic Dispensing Cabinets on Outcomes in Septic Shock"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9766-3970","authenticated-orcid":false,"given":"Sarah E.","family":"Pieterick","sequence":"first","affiliation":[{"name":"Mayo Clinic Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Wieruszewski","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Kannel","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Dierkhising","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica D.","family":"Wittwer","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-5186","authenticated-orcid":false,"given":"Patrick M.","family":"Wieruszewski","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5218-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03911-7"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.3046"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05401-y"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000001284"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-025-08204-5"},{"key":"e_1_3_5_9_2","volume-title":"Endo Announces Launch of ready-to-use VASOSTRICT\u00ae (Vasopressin Injection, USP) in Pre-mix Bottles PR Newswire","year":"2022","unstructured":"Endo Announces Launch of ready-to-use VASOSTRICT\u00ae (Vasopressin Injection, USP) in Pre-mix Bottles PR Newswire. Endo International plc 2022. https:\/\/www.prnewswire.com\/news-releases\/endo-announces-launch-of-ready-to-use-vasostrict-vasopressin-injection-usp-in-pre-mix-bottles-301476236.html"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006176"}],"container-title":["Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900261486608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08971900261486608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08971900261486608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:35:10Z","timestamp":1788665710000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08971900261486608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":10,"alternative-id":["10.1177\/08971900261486608"],"URL":"https:\/\/doi.org\/10.1177\/08971900261486608","relation":{},"ISSN":["0897-1900","1531-1937"],"issn-type":[{"value":"0897-1900","type":"print"},{"value":"1531-1937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"article-number":"08971900261486608"}}