{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:58:00Z","timestamp":1785333480877,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"21-22","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>Cerebral autoregulation (CA) plays a critical role in maintaining cerebral blood flow (CBF) amid fluctuations in systemic blood pressure, with dysfunction increasing vulnerability to secondary brain injury, particularly after traumatic brain injury (TBI). While extensively studied in adults, CA dynamics in pediatric TBI (pTBI) remain relatively unexplored. Studying Trends in AutoRegulation in Severe Head Injury in Pediatrics (STARSHIP), the first multicenter, prospective study on CA in pTBI, investigates the pressure reactivity index (PRx) and its association with outcomes. PRx, calculated as the Pearson\u2019s correlation between mean arterial pressure and intracranial pressure, provides insights into the patient\u2019s CA status. In this article, STARSHIP Part 2 characterizes PRx disturbances using dose metrics that take the magnitude of PRx disturbance, and the time in which the patient experiences this derangement, into consideration. We calculated the dose (overall and hourly) and percentage time spent with a PRx above thresholds 0\u20130.4 in 135 children with TBI. Associations with outcome were explored via summary metrics and over time, using uni- and multivariable, and ordinal regression with propensity score matching, correcting for known outcome predictors. Patients with poor outcomes exhibited higher PRx dose and percentage time above threshold, even after adjusting for clinical predictors. Time trend analyses highlighted elevated PRx metrics in poor outcome groups during the first-week post-injury. Duration of impaired pressure reactivity, as denoted by the percentage time a patient spent with a PRx &gt;0, is robustly and independently associated with dichotomized outcome at 12 months post-ictus. Our results highlight the predictive strength of PRx metrics, with percentage time above a threshold of 0 emerging as the most robust indicator of 12-month outcome. This work supports further investigation into the feasibility and impact of interventions guided by real-time CA monitoring in severe pTBI.<\/jats:p>","DOI":"10.1177\/08977151251367052","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T16:19:45Z","timestamp":1763396385000},"page":"1993-2003","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["STARSHIP Part 2: Disturbed Pressure Reactivity Duration and Magnitude in Pediatric Severe Traumatic Brain Injury\u2014Outcome Implications"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-6191","authenticated-orcid":false,"given":"Claudia Ann","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan 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