{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:02:34Z","timestamp":1785132154323,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Engineering Technology Research Center of Cardiopulmonary Cerebral Resuscitation in Henan Province Research Special Project","award":["202201281"],"award-info":[{"award-number":["202201281"]}]},{"name":"Henan Province Natural Science Foundation General Project","award":["232300420059"],"award-info":[{"award-number":["232300420059"]}]},{"DOI":"10.13039\/501100017700","name":"Henan Province Science and Technology Research Project","doi-asserted-by":"crossref","award":["242102310260"],"award-info":[{"award-number":["242102310260"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>\n                    Acute brain injury (ABI) is a severe neurological disorder in which inflammation and immune responses play a key role, with the Triggering Receptor Expressed on Myeloid Cells-1 (TREM1) being involved. Inhibition of TREM1 can alleviate neuroinflammation and damage, but the evidence from these pre-clinical studies remains unclear. This study summarizes and evaluates the results of animal experiments on the treatment of ABI with the TREM1 inhibitor LP17, exploring the effects of using LP17 to treat ABI animal models on neurological function, inflammatory indicators, and brain barrier function. As of April 30, 2025, this review conducted a detailed search of eight databases for studies on LP17 in ABI animal models. It performed a systematic review and meta-analysis of the included studies. The literature was independently screened, and data were extracted and assessed. RevMan 5.4 software was used for the meta-analysis. Compared with controls, the TREM1 inhibitor LP17 significantly reduced brain water content (standardized mean difference [SMD]: \u22121.36; 95% confidence interval [CI]: \u22121.77, \u22120.94;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001) and neurological deficit scores (SMD: \u22121.37; 95% CI: \u22121.76, \u22120.97;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001). It also decreased the expression of pro-inflammatory cytokines, including IL-1\u03b2 (SMD: \u22121.88; 95% CI: \u22122.63, \u22121.13;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001) and TNF-\u03b1 (SMD: \u22122.91; 95% CI: \u22123.89, \u22121.92;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001). LP17 mitigated blood\u2013brain barrier (BBB) disruption (SMD: \u22121.58; 95% CI: \u22122.47, \u22120.68;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.0005) and enhanced ZO-1 expression (SMD: 2.77; 95% CI: 1.73, 3.80;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001). It also inhibited the activation of nuclear factor-\u03baB (SMD: \u22121.70; 95% CI: \u22122.58, \u22120.83;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.0001), NLRP3 (SMD: \u22122.33; 95% CI: \u22123.27, \u22121.39;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001), and Caspase-1 (SMD: \u22122.03; 95% CI: \u22122.92, \u22121.14;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.00001). LP17 has neuroprotective effects in ABI animal models, likely through reducing neuroinflammation, preserving BBB integrity, and inhibiting apoptotic pathways. Further studies are needed to explore its mechanisms to better guide clinical use.\n                  <\/jats:p>","DOI":"10.1177\/08977151251392582","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:52:06Z","timestamp":1763455926000},"page":"515-530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Protective Effects of the Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor LP17 on Experimental Acute Brain Injury: A Systematic Review and Meta-Analysis Based on Animal Models"],"prefix":"10.1177","volume":"43","author":[{"given":"Lu","family":"Huang","sequence":"first","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China."},{"name":"Department of Critical Care Medicine of Henan Provincial Orthopedic Hospital\/Luoyang Orthopedic Hospital of Henan Province, Luoyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fifth Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, China."},{"name":"Emergency Medicine Department, Henan University of Chinese Medicine People\u2019s Hospital\/Zhengzhou People\u2019s Hospital, Zhengzhou, China."},{"name":"The Heart-Lung-Brain Resuscitation Engineering Technology Research Center of Henan Province, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China."},{"name":"Department of Critical Care Medicine of Henan Provincial Orthopedic Hospital\/Luoyang Orthopedic Hospital of Henan Province, Luoyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine of Henan Provincial Orthopedic Hospital\/Luoyang Orthopedic Hospital of Henan Province, Luoyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70104-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001432"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.5024"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(25)00089-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.046208"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.37145"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60371-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107212"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01263-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0421-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0443-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14255"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00840-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.148907"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101124"},{"key":"e_1_3_2_18_2","first-page":"523","article-title":"Role of TREM-1 in the formation of secondary brain injury after intracerebral hemorrhage in rats","author":"Duan HL","year":"2020","unstructured":"Duan HL, , Sun XG, , Zhang MM, et al. 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