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Acute signs and symptoms of mTBIs may involve physical symptoms, as well as emotional, cognitive, and sleep-related issues. The underlying mechanisms of these symptoms remain elusive. Here, we describe that repeated closed skull mTBIs in mice are associated with acute behavioral deficits. We found that optogenetic-induced spreading depolarizations (SDs) are associated with similar behavioral deficits. Using\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    electrophysiology, we confirmed the depression of cortical network activity following optogenetic-induced SDs. The timing of the high-frequency activity recovery coincided with the recovery of voluntary movement. Following the depression, there was a prolonged period of increased power in low frequencies (&lt;30 Hz). Cortical dysfunction coincided temporally with motor behavioral deficits in the neurological severity score tasks. Our study provides evidence that repeated mTBIs or SDs are associated with worse behavioral deficits.\n                  <\/jats:p>","DOI":"10.1177\/08977151261425217","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:05:21Z","timestamp":1773471921000},"page":"1506-1519","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Behavioral Deficits and Cortical Network Dysfunction Following Repeated Mild Traumatic Brain Injuries"],"prefix":"10.1177","volume":"43","author":[{"given":"Natalie J.","family":"Pinkowski","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA."},{"name":"Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA."},{"name":"Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, 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USA."},{"name":"Department of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA."},{"name":"Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA."},{"name":"Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA."},{"name":"Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell A.","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA."},{"name":"Center for Brain Recovery 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