{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:47:06Z","timestamp":1787881626168,"version":"build-2784847793"},"reference-count":97,"publisher":"SAGE Publications","issue":"17-18","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"crossref","award":["TR192003"],"award-info":[{"award-number":["TR192003"]}],"id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Traumatic brain injury (TBI) is a known risk factor for Alzheimer\u2019s disease and related neurodegenerative diseases. Sleep disturbances and epileptiform abnormalities can appear after TBI and may contribute to the development of neuropathology. In this study, we characterized sleep, epileptiform activity, and neuropathology after repetitive mild traumatic brain injury (rmTBI) in a mouse model of Alzheimer\u2019s disease. We used the Closed Head Impact Model of Engineered Rotational Acceleration to deliver rmTBI or sham (control) treatment to 6-month-old APP\/PS1 mice (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    = 19). One month post-injury, we implanted electroencephalogram and electromyographic electrodes, recorded for 72 h, and then collected brain tissue and blood plasma. Our assessment of sleep architecture showed that time spent in vigilance state was not affected by the rmTBI 1 month post-injury; however, power spectra analysis showed a shift toward higher frequencies in the rmTBI group during non-rapid eye movement sleep. Epileptiform activity did not differ between sham and rmTBI. Compared with sham controls, the rmTBI group showed higher neurofilament light (NF-L), but not glial fibrillary acidic protein in blood plasma and no change in A\u03b2 pathology. These results indicate sustained neurological injury in the APP\/PS1 mice 1 month after rmTBI without affecting amyloid deposition in the brain. Our study suggests that rmTBI can induce neural injury without causing enduring sleep disruption, seizures, and exacerbation of amyloidosis in the APP\/PS1 mouse model.\n                  <\/jats:p>","DOI":"10.1177\/08977151261430301","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:31:15Z","timestamp":1773642675000},"page":"1520-1534","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Repetitive Mild Traumatic Brain Injury Causes Neuronal Damage in the APP\/PS1 Mouse Model of Alzheimer\u2019s Disease Without an Enduring Impact on Amyloid Pathology, Sleep, or Epileptiform Activity"],"prefix":"10.1177","volume":"43","author":[{"given":"Jefferey","family":"Yue","sequence":"first","affiliation":[{"name":"Institute for Neuroscience and Neurotechnology, Simon Fraser University, Burnaby, British Columbia, Canada."},{"name":"Department of Molecular Biology and Biochemistry, 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Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Tok","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Neurotechnology, Simon Fraser University, Burnaby, British Columbia, Canada."},{"name":"Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Wellington","sequence":"additional","affiliation":[{"name":"Department of Pathology 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