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In the third survey, the participants were aged 46\u201350\u00a0years. Mobility limitations (none, some or severe) and falls (no falls, single fall or recurrent falls) were self-reported 2014\u20132016. Data (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 641) were analyzed using multinomial logistic regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In individual-level analysis a low level of physical activity in midlife was associated with severe mobility limitations. In within-twin pair analyses physical activity in midlife was associated with single falls among all pairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Lower levels of self-reported physical activity during midlife were associated with severe mobility limitations over two decades later. However, this association was attenuated when controlled for genetic factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08982643251395871","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:21:47Z","timestamp":1762946507000},"page":"704-714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Physical Activity in Midlife With Mobility Limitations and Falls in Old Age\u2014A Longitudinal Twin Study"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6555-1972","authenticated-orcid":false,"given":"Pia","family":"Pullinen","sequence":"first","affiliation":[{"name":"University of Jyv\u00e4skyl\u00e4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-9845","authenticated-orcid":false,"given":"Jari","family":"Parkkari","sequence":"additional","affiliation":[{"name":"University of Tampere"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-2455","authenticated-orcid":false,"given":"Jaakko","family":"Kaprio","sequence":"additional","affiliation":[{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-959X","authenticated-orcid":false,"given":"Elina","family":"Sillanp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"University of Jyv\u00e4skyl\u00e4"},{"name":"The Wellbeing Services County of Central Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-248X","authenticated-orcid":false,"family":"Harri Siev\u00e4nen","sequence":"additional","affiliation":[{"name":"The UKK Institute for Health Promotion Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-1992","authenticated-orcid":false,"given":"Urho","family":"Kujala","sequence":"additional","affiliation":[{"name":"University of Jyv\u00e4skyl\u00e4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-249X","authenticated-orcid":false,"given":"Katja","family":"Waller","sequence":"additional","affiliation":[{"name":"University of Jyv\u00e4skyl\u00e4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017378"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw060"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070854"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.276566"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12077"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003138"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61460-4"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000305"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2019.02.007"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00509.x"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/bjpt-rbf.2014.0095"},{"issue":"9","key":"e_1_3_7_13_1","first-page":"CD007146","article-title":"Interventions for preventing falls in older people living in the community","volume":"2012","author":"Gillespie L. 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