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Self-reported PA, depressive symptoms, and social isolation were assessed. MCI was defined as a composite cognitive score greater than one standard deviation below the sample mean.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Weighted path analysis showed that higher PA levels were inversely associated with MCI. Depressive symptoms and social isolation mediated this association. Social isolation moderated the PA\u2013MCI relationship, with the inverse association being most pronounced among individuals with higher isolation levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PA is associated with MCI in older adults through psychosocial pathways, and social isolation shapes this relationship. Promoting PA may be particularly relevant for those experiencing social isolation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08982643261475378","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:17:24Z","timestamp":1786061844000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial Pathways Between Physical Activity and Mild Cognitive Impairment in Community-Dwelling Older Adults: Mediation and Moderation Analyses"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0025-1275","authenticated-orcid":false,"given":"Daniel Eduardo","family":"da Cunha Leme","sequence":"first","affiliation":[{"name":"Florida State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-2985","authenticated-orcid":false,"given":"Mia Liza A.","family":"Lustria","sequence":"additional","affiliation":[{"name":"Florida State University"},{"name":"Florida State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-1759","authenticated-orcid":false,"given":"Dawn C.","family":"Carr","sequence":"additional","affiliation":[{"name":"Florida State University"},{"name":"Florida State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-3439","authenticated-orcid":false,"given":"Neil","family":"Charness","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-1836","authenticated-orcid":false,"given":"Kenneth M.","family":"Langa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-0244","authenticated-orcid":false,"given":"Zhe","family":"He","sequence":"additional","affiliation":[{"name":"Florida State University"},{"name":"Florida State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.103.3.411"},{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-81"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1502417"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0733464818807820"},{"key":"e_1_3_8_6_1","volume-title":"National Health and Nutrition Examination Survey: Analytic guidelines, 2011\u20132014 and 2015\u20132016","author":"Centers for Disease Control and Prevention","year":"2018","unstructured":"Centers for Disease Control and Prevention. 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