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The results demonstrated significant increases in scores and values of periodontal disease parameters associated with variable degrees of alveolar bone loss. The experimental maxillary premolar teeth exhibited more severe and rapid rates of periodontal disease compared with mandibular premolar teeth. Histometric analysis showed significant reduction in free and attached gingiva of the experimental teeth. Histopathological examination of buccolingual sections from experimental premolar teeth showed the presence of rete pegs within the sulcular epithelium with acanthosis and erosive changes, widening of the periodontal ligament, and alveolar bone resorption. Various methods for periodontal repair were studied in 194 experimental premolar teeth exhibiting different degrees of periodontal disease. The treatment plan comprised non-surgical (teeth scaling, root planing, and oral hygiene) and surgical methods (closed gingival curettage, modified Widman flap, and reconstructive surgery using autogenous bone marrow graft and canine amniotic membrane). The initial non-surgical treatment resulted in a periodontal recovery rate of 37.6 % and was found effective for treatment of early periodontal disease based on resolution of gingivitis and reduction of periodontal probing depths. Surgical treatment by closed gingival curettage to eliminate the diseased pocket lining resulted in a recovery rate of 48.8 % and proved effective in substantially reducing deep periodontal pockets. Open root planing following flap elevation resulted in a recovery rate of 85.4 % and was effective for deep and refractory periodontal pockets. Autogenous bone graft implantation combined with canine amniotic membrane as a biodegradable membrane was used in 18 premolar teeth and failed to improve advanced furcation defects in most teeth.<\/jats:p>","DOI":"10.1177\/089875640702400303","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T05:34:12Z","timestamp":1461821652000},"page":"152-165","source":"Crossref","is-referenced-by-count":16,"title":["Repair of Experimental Plaque-Induced Periodontal Disease in Dogs"],"prefix":"10.1177","volume":"24","author":[{"given":"M.","family":"Shoukry","sequence":"first","affiliation":[{"name":"From the Department of Veterinary Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine; the Department of Periodontology (Naby), Faculty of Oral and Dental Medicine, Cairo University, Egypt; and the Department of Veterinary Surgery (Ali), Faculty of Veterinary Medicine, Elfateh University, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Ben","family":"Ali","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine; the Department of Periodontology (Naby), Faculty of Oral and Dental Medicine, Cairo University, Egypt; and the Department of Veterinary Surgery (Ali), Faculty of Veterinary Medicine, Elfateh University, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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