{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:41:50Z","timestamp":1777858910157,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vet Dent"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>\n                    Tissue distribution, bioavailability, and efficacy of alendronate in preventing progression of resorption of teeth were evaluated in cats. [Butyl-4-\n                    <jats:sup>14<\/jats:sup>\n                    C-]-alendronate accumulates on subgingival tooth and alveolar bone surfaces adjacent to vascularized tissue resulting in concentration of the drug around tooth roots. Three cats were treated with a 0.03 mg\/kg IV bolus of [butyl-4-\n                    <jats:sup>14<\/jats:sup>\n                    C-]-alendronate followed by blood, urine, and feces collection and euthanasia 24-hours later. Drug tissue distribution was accessed by autoradiography and sample combustion. To assess bioavailability, 12 cats were administered alendronate orally (3.0 or 9.0 mg\/kg in water or 9.0 mg\/kg in tuna water) and urine was collected for 24-hours. In these formulations, alendronate oral bioavailability in cats was approximately 3 %. In addition, 10 cats with radiographic evidence of pre-existing tooth resorption (14 affected teeth) were treated with vehicle or 3.0 mg\/kg alendronate per os once weekly for 22-weeks and, then, 9.0 mg\/kg per os twice weekly for 27-weeks in a random, masked study. Radiographic area of resorption was measured and progression scored every 3 to 4-months.\n                  <\/jats:p>\n                  <jats:p>In placebo-treated cats, resorption progressed in five of six teeth (+ 97 % average increase in area of resorption), whereas progression of resorption was seen in only three of eight affected teeth in alendronate-treated cats with a \u2013 22 % average change (decrease) in area (P &lt; 0.01 difference in number of teeth showing progression; P &lt; 0.001 difference in area of resorption).<\/jats:p>\n                  <jats:p>Alendronate accumulated preferentially on subgingival tooth surfaces and adjacent alveolar bone and, at a dose of 9 mg\/kg twice weekly, effectively slowed or arrested the progression of resorption.<\/jats:p>","DOI":"10.1177\/089875640902600201","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T05:34:12Z","timestamp":1461821652000},"page":"74-81","source":"Crossref","is-referenced-by-count":21,"title":["Alendronate Binds to Tooth Root Surfaces and Inhibits Progression of Feline Tooth Resorption: A Pilot Proof-of-Concept Study"],"prefix":"10.1177","volume":"26","author":[{"given":"Kenneth L.","family":"Mohn","sequence":"first","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Jacks","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Dieter","family":"Schleim","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin E.","family":"Harvey","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Miller","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Halley","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William P.","family":"Feeney","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Hill","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerry","family":"Hickey","sequence":"additional","affiliation":[{"name":"From the Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900 (Mohn, Jacks, Schleim, Feeney, Hill, Hickey), Pharmaceutical Research and Development (Halley), Merial Limited, 631 US Route 1 South, North Brunswick, NJ 08902; and the Department of Clinical Studies-Philadelphia (Harvey, Miller), University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 119104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"bibr1-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1177\/089875649501200301"},{"key":"bibr2-089875640902600201","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.230"},{"key":"bibr3-089875640902600201","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1998.212.03.392"},{"key":"bibr4-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(92)50134-6"},{"key":"bibr5-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(86)50305-3"},{"key":"bibr6-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.55.329"},{"key":"bibr7-089875640902600201","first-page":"216","volume":"29","author":"Ohba S","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr8-089875640902600201","first-page":"1461","volume":"17","author":"Okuda A","year":"1995","journal-title":"Compend Contin Educ Pract Vet"},{"key":"bibr9-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(92)50135-8"},{"key":"bibr10-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1177\/089875649501200105"},{"key":"bibr11-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1177\/089875649501200101"},{"key":"bibr12-089875640902600201","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.1866"},{"key":"bibr13-089875640902600201","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0090-9556(25)08972-X","volume":"19","author":"Lin JH","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"bibr14-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.1.0325"},{"key":"bibr15-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118722"},{"key":"bibr16-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.3.211"},{"key":"bibr17-089875640902600201","doi-asserted-by":"publisher","DOI":"10.3109\/03008200009005289"},{"key":"bibr18-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(92)50133-4"},{"key":"bibr19-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000327"},{"key":"bibr20-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.6.1742S"},{"key":"bibr21-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000242"},{"key":"bibr22-089875640902600201","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0090-9556(25)08729-X","volume":"20","author":"Lin JH","year":"1992","journal-title":"Drug Metab Dispos"},{"key":"bibr23-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(92)80551-Z"},{"key":"bibr24-089875640902600201","first-page":"201","volume":"19","author":"Kavantzas N","year":"2000","journal-title":"J Exp Clin Cancer Res"},{"key":"bibr25-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1159\/000028817"},{"key":"bibr26-089875640902600201","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0090-9556(25)08706-9","volume":"20","author":"Lin JH","year":"1992","journal-title":"Drug Metab Dispos"},{"key":"bibr27-089875640902600201","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0090-9556(25)08972-X","volume":"19","author":"Lin JH","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"bibr28-089875640902600201","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90245-7"},{"key":"bibr29-089875640902600201","first-page":"1","volume":"26","author":"Henriksen PA","year":"1972","journal-title":"Acta Odontol Scand"}],"container-title":["Journal of Veterinary Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/089875640902600201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/089875640902600201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:22:03Z","timestamp":1777508523000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/089875640902600201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1177\/089875640902600201"],"URL":"https:\/\/doi.org\/10.1177\/089875640902600201","relation":{},"ISSN":["0898-7564","2470-4083"],"issn-type":[{"value":"0898-7564","type":"print"},{"value":"2470-4083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}