{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:14:27Z","timestamp":1788452067007,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vet Dent"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Periodontal disease is an inflammatory disease that has numerous consequences both locally and systemically. The aim of this study was to assess whether periodontal disease causes systemic inflammatory response in otherwise healthy, adult dogs. We estimated the total mouth periodontal score (TMPS), measured the concentration of C-reactive protein (CRP), hematocrit, and albumin, and determined the white blood cell (WBC) and polymorphonuclear cell (PMN) counts in client-owned dogs. There was a statistically significant relationship between the gingival bleeding index (TMPS-G) and CRP concentration, and WBC and PMN counts, possibly during the active periods of periodontal tissue destruction. No correlation was found between the periodontal destruction index (TMPS-P) and the measured blood parameters. We conclude that chronic periodontal disease does not cause anemia or a reduction in serum albumin. However, active periods of periodontal inflammation may be associated with laboratory values suggestive of a systemic inflammatory response.<\/jats:p>","DOI":"10.1177\/089875641303000103","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T05:34:12Z","timestamp":1461821652000},"page":"26-29","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Periodontal Disease as a Potential Factor for Systemic Inflammatory Response in the Dog"],"prefix":"10.1177","volume":"30","author":[{"given":"MI","family":"Kouki","sequence":"first","affiliation":[{"name":"From the Companion Animal Clinic, Department of Clinical Science, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki (A.U.Th.) 11, St. Voutyra Street, 54627, Thessaloniki, Greece; and, Progress Laboratories (Bitchava) 17, 28th Oktovriou Str, Markopoulo Attiki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"From the Companion Animal Clinic, Department of Clinical Science, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki (A.U.Th.) 11, St. Voutyra Street, 54627, Thessaloniki, Greece; and, Progress Laboratories (Bitchava) 17, 28th Oktovriou Str, Markopoulo Attiki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GM","family":"Kazakos","sequence":"additional","affiliation":[{"name":"From the Companion Animal Clinic, Department of Clinical Science, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki (A.U.Th.) 11, St. Voutyra Street, 54627, Thessaloniki, Greece; and, Progress Laboratories (Bitchava) 17, 28th Oktovriou Str, Markopoulo Attiki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Savas","sequence":"additional","affiliation":[{"name":"From the Companion Animal Clinic, Department of Clinical Science, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki (A.U.Th.) 11, St. Voutyra Street, 54627, Thessaloniki, Greece; and, Progress Laboratories (Bitchava) 17, 28th Oktovriou Str, Markopoulo Attiki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bitchava","sequence":"additional","affiliation":[{"name":"From the Companion Animal Clinic, Department of Clinical Science, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki (A.U.Th.) 11, St. Voutyra Street, 54627, Thessaloniki, Greece; and, Progress Laboratories (Bitchava) 17, 28th Oktovriou Str, Markopoulo Attiki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"bibr1-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(98)50105-2"},{"key":"bibr2-089875641303000103","first-page":"89","volume-title":"Small animal dentistry","author":"Harvey CE","year":"1992"},{"key":"bibr3-089875641303000103","volume-title":"Contribution to the study of epidemiology and pathogenesis in canine periodontal disease","author":"Papadimitriou SE","year":"2001"},{"key":"bibr4-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01305.x"},{"key":"bibr5-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2008.02.003"},{"key":"bibr6-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.00011.x"},{"key":"bibr7-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2065.215"},{"key":"bibr8-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1989.tb00860.x"},{"key":"bibr9-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1177\/089875649601300201"},{"key":"bibr10-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb01743.x"},{"key":"bibr11-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(98)50102-7"},{"key":"bibr12-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1177\/089875640802500210"},{"key":"bibr13-089875641303000103","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.4.486"},{"key":"bibr14-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1366.032"},{"key":"bibr15-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2106"},{"key":"bibr16-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1221"},{"key":"bibr17-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300214"},{"key":"bibr18-089875641303000103","doi-asserted-by":"publisher","DOI":"10.3923\/jms.2008.191.195"},{"key":"bibr19-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00019.x"},{"key":"bibr20-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(03)00119-9"},{"key":"bibr21-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.261006.x"},{"key":"bibr22-089875641303000103","first-page":"150","volume":"3","author":"Rai B","year":"2009","journal-title":"African J of Biochem Res"},{"key":"bibr23-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028010930.x"},{"key":"bibr24-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1177\/089875640802500303"},{"key":"bibr25-089875641303000103","first-page":"239","volume-title":"Periodontology","author":"Konstantinidis AB","year":"2003"},{"key":"bibr26-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1002\/9780470753187.ch2"},{"key":"bibr27-089875641303000103","first-page":"55","volume-title":"Saunders solutions in veterinary practice-small animal dentistry","author":"Gorrel C","year":"2008"},{"key":"bibr28-089875641303000103","first-page":"96","volume-title":"BSAVA manual of canine and feline dentistry","author":"Caiafa A","year":"2007","edition":"3"},{"key":"bibr29-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01281.x"},{"key":"bibr30-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.420"},{"key":"bibr31-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"bibr32-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.1007"},{"key":"bibr33-089875641303000103","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.5.601"},{"key":"bibr34-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.70.127"},{"key":"bibr35-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822007000100006"},{"key":"bibr36-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200202"},{"key":"bibr37-089875641303000103","first-page":"52","volume-title":"Small animal clinical diagnosis by laboratory methods","author":"Latimer KS","year":"2004","edition":"4"},{"key":"bibr38-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2006.00203.x"},{"key":"bibr39-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010701"},{"key":"bibr40-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.10.007"},{"key":"bibr41-089875641303000103","first-page":"1160","volume-title":"Small animal internal medicine","author":"Nelson RW","year":"1998","edition":"2"},{"key":"bibr42-089875641303000103","first-page":"205","volume-title":"Schalm's veterinary hematology","author":"Waner T","year":"2000","edition":"5"},{"key":"bibr43-089875641303000103","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.22.7330-7339.1991"}],"container-title":["Journal of Veterinary Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/089875641303000103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/089875641303000103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:22:39Z","timestamp":1777508559000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/089875641303000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/089875641303000103"],"URL":"https:\/\/doi.org\/10.1177\/089875641303000103","relation":{},"ISSN":["0898-7564","2470-4083"],"issn-type":[{"value":"0898-7564","type":"print"},{"value":"2470-4083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}