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Clinical signs vary depending on tumor location. The tumor commonly arises from the gingiva and mucosa of the maxilla, mandible, tongue, sublingual area, or tonsillar region. Maxillary SCC commonly presents clinically as an ulcerative lesion, whereas mandibular SCC is commonly proliferative, expansile, and firm. Lingual\/sublingual SCC may be ulcerative, necrotic, infiltrative, or proliferative. In general, feline oral SCC is an invasive and malignant neoplasm regardless of its location. Surgery, radiation therapy, chemotherapy and combinations thereof have been attempted with rarely a satisfactory response. Currently, cures are obtained only in a small subset of cats whose tumors are amenable to complete resection, or where resection with microscopic residual disease is followed by definitive radiation therapy. A multimodal treatment approach likely offers the best chance of success. For cats with advanced disease, palliative care may improve patients' quality of life, albeit transiently. Sequelae associated with tumor progression and local tissue destruction often result in euthanasia of feline patients with oral SCC.<\/jats:p>","DOI":"10.1177\/089875641503200104","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T05:34:12Z","timestamp":1461821652000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":87,"title":["Feline Oral Squamous Cell Carcinoma: Clinical Manifestations and Literature Review"],"prefix":"10.1177","volume":"32","author":[{"given":"Ozgur","family":"Bilgic","sequence":"first","affiliation":[{"name":"From the Town and Country Veterinary Hospital, 10350 Bandera Road, San Antonio, TX 78250 (Bilgic); the Mari Lowe Center for Comparative Oncology (Duda); Department of Pathobiology (S\u00e1nchez), Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA, 19104-6010; and, NorthStar Veterinary Emergency Trauma and Specialty Center (Lewis)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Duda","sequence":"additional","affiliation":[{"name":"From the Town and Country Veterinary Hospital, 10350 Bandera Road, San Antonio, TX 78250 (Bilgic); 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