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An incisional biopsy was acquired, submitted, and interpreted as a possible granular cell tumor based on hematoxylin and eosin, and periodic acid Schiff histopathologic staining characteristics. The diagnosis was supported by immunohistochemical evaluation that was positive for S-100, vimentin, and neuron-specific enolase. Based on the absence of mitotic figures in the incisional biopsy, a partial glossectomy was performed with gross margins of at least 1-cm. The excisional biopsy revealed significant features of malignancy, with neoplastic cells in close association with peripheral nerves, consistent with malignant peripheral nerve sheath tumor. Tumor-free margins were obtained, and the glossectomy had expected healing with no recurrence apparent 6-months following surgery.<\/jats:p>","DOI":"10.1177\/089875641503200303","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T05:34:12Z","timestamp":1461821652000},"page":"165-172","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Lingual Malignant Peripheral Nerve Sheath Tumor in a Chinese Pug Dog"],"prefix":"10.1177","volume":"32","author":[{"given":"Robert M.","family":"Baratt","sequence":"first","affiliation":[{"name":"From 12 Center Street, Salem, CT 06420 (Baratt); the Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Rawlinson); and IDEXX Laboratories, 3 Centennial Drive, North Grafton, MA, 01535 (Roth-Johnson, Jones)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"From 12 Center Street, Salem, CT 06420 (Baratt); the Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Rawlinson); and IDEXX Laboratories, 3 Centennial Drive, North Grafton, MA, 01535 (Roth-Johnson, Jones)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Roth-Johnson","sequence":"additional","affiliation":[{"name":"From 12 Center Street, Salem, CT 06420 (Baratt); the Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Rawlinson); and IDEXX Laboratories, 3 Centennial Drive, North Grafton, MA, 01535 (Roth-Johnson, Jones)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll J.","family":"Jones","sequence":"additional","affiliation":[{"name":"From 12 Center Street, Salem, CT 06420 (Baratt); the Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 (Rawlinson); and IDEXX Laboratories, 3 Centennial Drive, North Grafton, MA, 01535 (Roth-Johnson, Jones)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"bibr1-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1970.tb07038.x"},{"key":"bibr2-089875641503200303","first-page":"1776","volume":"25","author":"Cohen D","year":"1964","journal-title":"Am J Vet Res"},{"key":"bibr3-089875641503200303","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2460\/javma.1976.169.11.1202","volume":"169","author":"Dorn CR","year":"1976","journal-title":"J Am Vet Med Assoc"},{"key":"bibr4-089875641503200303","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2460\/javma.1979.175.06.567","volume":"175","author":"Todoroff RJ","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"bibr5-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1983.tb00349.x"},{"key":"bibr6-089875641503200303","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.10.1533"},{"key":"bibr7-089875641503200303","doi-asserted-by":"publisher","DOI":"10.5326\/0440308"},{"key":"bibr8-089875641503200303","first-page":"525","volume":"22","author":"Beck ER","year":"1986","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr9-089875641503200303","first-page":"630","volume":"58","author":"Wimmer N","year":"2013","journal-title":"Kleinteripraxis"},{"key":"bibr10-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2001.tb00260.x"},{"key":"bibr11-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-4-307"},{"key":"bibr12-089875641503200303","doi-asserted-by":"publisher","DOI":"10.5326\/0400331"},{"key":"bibr13-089875641503200303","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.10.1392"},{"key":"bibr14-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4618-6.00044-0"},{"key":"bibr15-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00342.x"},{"key":"bibr16-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199807000-00001"},{"key":"bibr17-089875641503200303","first-page":"152","volume-title":"WHO classification of tumors, pathology and genetics of head and neck tumors","author":"Thompson LDR","year":"2005"},{"key":"bibr18-089875641503200303","first-page":"147","volume-title":"WHO classification of tumors, pathology and genetics of head and neck tumors","author":"Thompson LDR","year":"2005"},{"key":"bibr19-089875641503200303","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2006.10.003"},{"key":"bibr20-089875641503200303","doi-asserted-by":"crossref","unstructured":"Akdesir E. 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