{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:14:59Z","timestamp":1788452099535,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"crossref","award":["P4-0053,P4-0092,P3-0067,P1-0143,J1-6744,J3-3082"],"award-info":[{"award-number":["P4-0053,P4-0092,P3-0067,P1-0143,J1-6744,J3-3082"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vet Dent"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>The effects on the stress response, postanesthetic sedation, and altered behavior were evaluated following regional anesthesia and dental treatment in 40 dogs. Serum cortisol and blood glucose concentrations were measured following the administration of levobupivacaine (LBUP) 0.5% and dexmedetomidine (DEX) (0.5\u2005\u00b5g\/kg) or a placebo. The dogs were randomly assigned to 4 groups of 10 dogs each. All dogs received a regional nerve block using LBUP 0.5%. Group 1 (LBUP\u2009+\u2009DEX IV) also received DEX intravenously (IV); group 2 (LBUP\u2009+\u2009PLC IV) also received a placebo IV; group 3 (LBUP\u2009+\u2009DEX IO) also received DEX in one infraorbital (IO) block; and group 4 (LBUP\u2009+\u2009DEX IA) also received DEX in one inferior alveolar (IA) block. Serum cortisol and blood glucose concentrations were determined before the administration of oral blocks and at the end of the procedure. Sedation and behavior scores were assessed before premedication and hourly for 6\u2005h after the end of anesthesia. Cortisol concentration did not change in any group at either evaluation time. The glucose concentration was higher ( P\u2009&lt;\u2009.05) only in the LBUP\u2009+\u2009DEX IA group at the end of the procedure. The sedation score was higher until the end of the observation period only in the LBUP\u2009+\u2009DEX IV and LBUP\u2009+\u2009PLC IV groups. No change in behavior score was observed in any of the groups. The reduction of perioperative stress response in all groups was due to the use of LBUP and not DEX.<\/jats:p>","DOI":"10.1177\/08987564241270598","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T09:27:41Z","timestamp":1723800461000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Cortisol and Blood Glucose Concentrations in Anesthetized Dogs Administered Levobupivacaine and Low-Dose Dexmedetomidine for Regional Anesthesia of the Oral Cavity"],"prefix":"10.1177","volume":"42","author":[{"given":"Matic","family":"Pavlica","sequence":"first","affiliation":[{"name":"Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojca","family":"Kr\u017ean","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Toxicology, 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