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This article presents 2 case reports of dogs with amelanotic oral melanoma that were both diagnostically challenging. Case 1 is a sparsely pigmented, spindle cell oral melanoma that was initially diagnosed as benign fibrous hyperplasia and subsequently suspected to be fibrosarcoma. Case 2 is an amelanotic oral melanoma that was originally diagnosed as an extramedullary plasmacytoma. This report highlights features of each of the cases while also discussing strategies to optimize the diagnosis of oral melanoma in dogs. 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