{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:08:59Z","timestamp":1778400539190,"version":"3.51.4"},"reference-count":75,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vet Dent"],"abstract":"<jats:p>\n                    Halitosis, or oral malodor, is caused by unwanted oral microbes that metabolize proteins and produce volatile sulfur compounds (VSCs). These malodorous VSCs may negatively impact oral health as they are pro-inflammatory, and halitosis is generally considered an important marker of oral health status. A previous clinical study with 24 dogs showed that daily administration of 250\u2005mg of a novel canine oral health postbiotic (COHP) significantly decreased VSCs by 26% compared to placebo on Day 14, with twice as many dogs showing perceptibly improved breath in the COHP group on Day 7. The present double-blinded, placebo-controlled validation study evaluated COHP's ability to reduce canine oral malodor at a reduced dose of 150\u2005mg to confirm that the previously reported efficacy of COHP is reproducible and maintained at a lower dose. Twenty-four dogs were stratified by starting VSC levels and received either COHP or placebo as a powder topper over standard chow for 14 days. VSC levels were measured via a halimeter, and perceived malodor was assessed using a 10-point scale on Days 0, 7, and 14. VSC levels increased in the placebo group by 24% on Day 7 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.006) and 38% on Day 14 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.002), while COHP prevented VSC increases on both days, resulting in a \u221226% change compared to placebo on Day 14 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.04). VSC levels correlated with perceived malodor, and COHP trended toward a 1-point reduction in perceived malodor compared to placebo (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.06). These findings agree with the previous study, suggesting COHP effectively reduces canine halitosis across 2 doses.\n                  <\/jats:p>","DOI":"10.1177\/08987564261437296","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:57:05Z","timestamp":1778158625000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Canine Halitosis Improved With a Postbiotic: A Validation Study"],"prefix":"10.1177","author":[{"given":"Aylesse","family":"Sordillo","sequence":"first","affiliation":[{"name":"Kingdom, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-4190","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Turcotte","sequence":"additional","affiliation":[{"name":"Kingdom, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi U.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Kingdom, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05292-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-022-03267-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40391-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.09.036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.61872\/sdj-2019-12-589"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0189-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-737X2012000400003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00298"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194415"},{"issue":"2","key":"e_1_3_3_11_2","first-page":"192","article-title":"Association between halitosis and periodontal disease related parameters in dogs","volume":"24","author":"Kim SE","year":"2007","unstructured":"Kim SE, Shim KM, Yoo KH, et al. 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