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Exercise has been shown to influence hippocampal long-term potentiation (LTP) and memory, and is neuroprotective in several neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine the impact of intense running in HR mice with wheel access on hippocampal LTP, compared to HR mice without wheels and non-selected control (C) mice with\/without wheels. Additionally, we investigated the involvement of D1\/D5 receptors and the dopamine transporter (DAT) in LTP modulation and examined levels of these proteins in HR and C mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult female HR and C mice were individually housed with\/without running wheels for at least two weeks. Hippocampal LTP of extracellular field excitatory postsynaptic potentials (fEPSPs) was measured in area CA1, and SKF-38393 (D1\/D5 receptor agonist) and GBR 12909 (DAT inhibitor) were used to probe the role of D1\/D5 receptors and DAT in LTP differences. Western blot analyses assessed D1\/D5 receptor and DAT expression in the hippocampus, prefrontal cortex, and cerebellum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HR mice with wheel access showed significantly increased hippocampal LTP compared to those without wheels and to C mice with\/without wheels. Treatment with SKF-38393 or GBR 12909 prevented the heightened LTP in HR mice with wheels, aligning it with levels in C mice. Hippocampal D1\/D5 receptor levels were lower, and DAT levels were higher in HR mice compared to C mice. No significant changes were observed in other brain regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increased hippocampal LTP seen in HR mice with wheel access may be related to alterations in dopaminergic synaptic transmission that underlie the neurophysiological basis of hyperactivity, motor disorders, and\/or motivation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09226028241290400","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T01:08:35Z","timestamp":1733101715000},"page":"193-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hippocampal long-term potentiation is modulated by exercise-induced alterations in dopaminergic synaptic transmission in mice selectively bred for high voluntary wheel running"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-3952","authenticated-orcid":false,"given":"Jessica Mai-Phuong","family":"Phan","sequence":"first","affiliation":[{"name":"Program in Molecular Biology, Pomona College, Claremont, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Pomona College, Claremont, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Hope Amor","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Pomona College, Claremont, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia Rei Katsura","family":"Ayabe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Pomona College, Claremont, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Pomona College, Claremont, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Theodore","family":"Garland","sequence":"additional","affiliation":[{"name":"Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Diane","family":"Parfitt","sequence":"additional","affiliation":[{"name":"Program in Molecular Biology, Pomona College, Claremont, CA, USA"},{"name":"Department of Neuroscience, Pomona College, Claremont, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.03.007"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.589621"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113741"},{"issue":"9","key":"e_1_3_5_5_1","first-page":"2079","article-title":"The evolution of gene expression in mouse hippocampus in response to selective breeding for increased locomotor activity","volume":"58","author":"Bronikowski A. 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