{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:03:23Z","timestamp":1784937803895,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Episodic memory deficits are frequently encountered following stroke. Rehabilitation of these deficits is often associated with short term effects that do not persist at follow up times. Neuromodulation tools acting on alterations of excitation\/inhibition dynamics could be useful for rehabilitation of episodic memory. Prism adaptation with visual field deviation ipsilateral to the affected hemisphere can specifically modulate brain excitability and lead to improvement of cognitive deficits in post-stroke patients. Here we investigated whether prism adaptation followed by digital cognitive training could induce long term improvement of episodic memory deficits in stroke patients as compared with traditional rehabilitation.<\/jats:p>\n                  <jats:p>\n                    Sixty stroke patients were recruited for the study. Thirty patients were treated with prism adaptation combined with serious games targeting executive processes, with a ten days protocol (\n                    <jats:underline>experimental group<\/jats:underline>\n                    ); thirty patients were treated with conventional rehabilitation (\n                    <jats:underline>control<\/jats:underline>\n                    <jats:underline>group<\/jats:underline>\n                    ). Patients were tested with a battery of neuropsychological tests, including verbal and visual episodic memory tasks at four times: at baseline (T0); immediately after the end of the rehab protocol (T1); after 3 months (T2); after six months (T3).\n                  <\/jats:p>\n                  <jats:p>The main results showed a significant long term effect of the experimental treatment on both immediate and delayed recall phases of the visual episodic memory task. The effects were not linked to the affected hemisphere (right vs. left), nor to the hemorrhagic or ischemic type of stroke nor to the cortical or subcortical site of lesion.<\/jats:p>\n                  <jats:p>These findings show for the first time an improvement of long term memory in stroke patients following the use of a medical device combining prism adaptation and digital cognitive training, paving the way to novel rehabilitation techniques for cognitive deficits in stroke.<\/jats:p>","DOI":"10.1177\/09226028241301367","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T03:23:57Z","timestamp":1740021837000},"page":"399-408","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long Term Improvement of Episodic Memory in Stroke Patients Following a Short Treatment with Prism Adaptation and Serious Games"],"prefix":"10.1177","volume":"44","author":[{"given":"Massimiliano","family":"Oliveri","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy"},{"name":"Neuropsychology Lab, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Stanzione","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Caruso","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Di Garbo","sequence":"additional","affiliation":[{"name":"Neuropsychology Lab, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Turriziani","sequence":"additional","affiliation":[{"name":"Neuropsychology Lab, University of Palermo, Palermo, Italy"},{"name":"Department SPPEF, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Augusto","family":"Carlesimo","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia IRCCS, Rome, Italy"},{"name":"Neurology Department, University of Rome Tor Vergata, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000891"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.05.006"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1422-17.2017"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117297"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000092122.96722.72"},{"issue":"1","key":"e_1_3_2_7_1","first-page":"7148","article-title":"Prismatic adaptation coupled with cognitive training as novel treatment for developmental dyslexia: A randomized controlled trial","volume":"14","author":"Conte G.","year":"2024","unstructured":"Conte G., Quadrana L., Zotti L., Di Garbo A., Oliveri M. (2024). Prismatic adaptation coupled with cognitive training as novel treatment for developmental dyslexia: A randomized controlled trial. Sci Reports, 14(1), 7148. https:\/\/doi.org\/10.1038\/s41598-024-57499-9","journal-title":"Sci Reports"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2023.108557"},{"issue":"9","key":"e_1_3_2_9_1","article-title":"Cognitive rehabilitation for memory deficits after stroke","volume":"9","author":"das Nair R.","year":"2016","unstructured":"das Nair R., Cogger H., Worthington E., Lincoln N. B. (2016). Cognitive rehabilitation for memory deficits after stroke. Cochrane Database Syst Rev, 9(9), CD002293. https:\/\/doi.org\/10.1002\/14651858.CD002293.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1268337"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241238637"},{"issue":"2","key":"e_1_3_2_12_1","first-page":"49","article-title":"The bells test: A quantitative and qualitative test for visual neglect","volume":"11","author":"Gauthier L.","year":"1989","unstructured":"Gauthier L., Dehaut F., Joanette Y. (1989). The bells test: A quantitative and qualitative test for visual neglect. Int J Clin Neuropsychol, 11(2), 49\u201354.","journal-title":"Int J Clin Neuropsychol"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(03)00110-4"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2024.108789"},{"key":"e_1_3_2_15_1","doi-asserted-by":"crossref","unstructured":"Harquel S. Cadic-Melchior A. Morishita T. et al. (2024). Stroke Recovery-Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition Stroke Apr 19. https:\/\/doi.org\/10.1161\/STROKEAHA.123.045174. Online ahead of print.","DOI":"10.1161\/STROKEAHA.123.045174"},{"issue":"11","key":"e_1_3_2_16_1","article-title":"Virtual reality for stroke rehabilitation","volume":"11","author":"Laver K. E.","year":"2017","unstructured":"Laver K. E., Lange B., George S., Deutsch J. E., Saposnik G., Crotty M. (2017). Virtual reality for stroke rehabilitation. 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