{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:52:42Z","timestamp":1777924362420,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system, leading to inflammation, demyelination, and neurodegeneration. Although disease-modifying therapies (DMTs) have shown efficacy in reducing relapse rates, they offer limited benefit in addressing cognitive symptoms and overall disease burden. The ketogenic diet (KD), a high-fat, low-carbohydrate dietary approach, has emerged as a promising adjunctive strategy. Recent research suggests that KD may modulate key inflammatory pathways, enhance mitochondrial function, and reduce oxidative stress through mechanisms involving ketone bodies such as \u03b2-hydroxybutyrate. These effects have been linked to improvements in fatigue, cognition, quality of life, and markers of neuronal injury in individuals with MS. Furthermore, KD may positively influence the gut microbiome, insulin sensitivity, and myelin repair processes. Despite encouraging results, challenges such as dietary adherence, nutrient deficiencies, gastrointestinal side effects, and cardiovascular risks limit widespread adoption. Current evidence is largely based on short-term studies with limited diversity and variable dietary protocols. Future research should focus on long-term safety, standardized guidelines, and personalized strategies to better integrate KD into comprehensive MS care.<\/jats:p>","DOI":"10.1177\/09226028251404071","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:58:58Z","timestamp":1765385938000},"page":"28-36","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Ketogenic Diet as Adjunctive Therapy in Multiple Sclerosis: A Review"],"prefix":"10.1177","volume":"44","author":[{"given":"Sana","family":"Rasheed","sequence":"first","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Uzair","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaqat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Anas","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Bacha Khan College of Dentistry, Mardan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda Sakina","family":"Batool Naqvi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umaima","family":"Aijaz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2930-8188","authenticated-orcid":false,"given":"Ahmed Asad","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8614-3924","authenticated-orcid":false,"given":"Abedin","family":"Samadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kabul University of Medical Sciences, Kabul, Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3928-9"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051156"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.07.025"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.08.057"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001102"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20899"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000565"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-329074"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001007"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.009"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00363-7"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14235003"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac154"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.02012"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105897"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037297"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17182969"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.16084"},{"key":"e_1_3_3_20_1","unstructured":"Keto-Like\u2019 Diet May be Linked to Increased Risk of Heart Disease \u2013 Centre for Heart Lung Innovation [Internet]. 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