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Forty-six patients completed the intervention. The primary outcome was pain intensity scored on a numerical rating scale (NRS). Secondary outcomes included verbal fluency and self-reports of affective pain, quality of life, sleep quality, mood, emotion regulation, and psychological impairment. Transcranial magnetic stimulation was used to measure mindfulness-induced cortical excitability changes. Participants reported statistically reduced pain intensity post-training, with only 15.3% of the patients demonstrating clinically meaningful pain relief. A moderate improvement in quality of life, with only 45.6% clinical responders, were noted. Small-to-medium improvements in affective pain level, mindfulness level, and resilience as well as increase in long-interval intracortical inhibition\u2014a measure of GABA\n                    <jats:sub>B<\/jats:sub>\n                    ergic inhibition\u2014were observed. The study introduces a novel MBI tailored for fibromyalgia. Nonetheless, given the current study design and the lack of clinical significance of the findings despite statistical significance, the results are insufficient to draw firm conclusions regarding its potential therapeutic efficacy. Future sham-controlled randomized clinical trials are necessary to validate and expand upon these results.\n                  <\/jats:p>","DOI":"10.1177\/09226028251410014","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T19:08:42Z","timestamp":1768331322000},"page":"329-348","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Brief Mindfulness Intervention for Pain Management in Fibromyalgia: A Single-arm Open-Label Study"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3778-3463","authenticated-orcid":false,"given":"Perianen","family":"Ramasawmy","sequence":"first","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"},{"name":"Pain Clinic, Department of Anesthesiology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise Charlotte","family":"Heim","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fechner","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Enrico","family":"Schumann","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy Tien","family":"Mai","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Moschner","sequence":"additional","affiliation":[{"name":"Institute of Computer and Communication Technology, Technische Hochschule K\u00f6ln, K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Guo","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Lesani","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-8889","authenticated-orcid":false,"given":"Frank","family":"Petzke","sequence":"additional","affiliation":[{"name":"Pain Clinic, Department of Anesthesiology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Antal","sequence":"additional","affiliation":[{"name":"Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center G\u00f6ttingen, Georg-August University, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-5320","authenticated-orcid":false,"given":"Olga-Lucia","family":"Gamboa Arana","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Sydney, Sydney, Australia"},{"name":"EQness, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"2161","article-title":"Validation of an adapted Arabic version of fibromyalgia syndrome impact questionnaire","volume":"33","author":"Abd El-Naby M.","year":"2013","unstructured":"Abd El-Naby M., Ahmed Hefny M., Fahim A. 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