{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:03:23Z","timestamp":1784937803902,"version":"3.55.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Post-acute COVID-19 vaccination syndrome (PACVS) emerges as a syndrome of persistent symptoms of a multisystemic nature, even in previously healthy people. Its pathophysiology involves a neural phase characterized by the neuroimmune reflex and persistent secondary neurogenic inflammation. Frequent manifestations such as dysautonomia, neurological alterations, and musculoskeletal symptoms have been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the current evidence on PACVS and explore the therapeutic potential of Neuraltherapeutic Medicine (NTM), illustrated with a clinical case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A targeted literature review search was conducted in MEDLINE (up to June 2024) using the terms \u201cpost-COVID-19 vaccination syndrome\u201d, \u201ccovid vaccine adverse effects\u201d, \u201cinflammatory reflex\u201d and \u201cneural therapy\u201d. In addition, a clinical case of a 75-year-old patient with persistent musculoskeletal pain post-vaccination, treated with NTM, was documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pathophysiology of PACVS includes neuroimmune mechanisms such as response, neurogenic inflammation, and autonomic dysfunction. NTM has shown the ability to modulate the nervous system by desensitizing sources of irritation. In the case presented, the application of 0.5% procaine to the vaccination site and contralateral reflex zone resulted in complete resolution of pain within 48\u2005h and sustained functional improvement during the three months of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NTM could represent a therapeutic option in the management of PACVS and other syndromes involving neurogenic inflammation. Controlled studies are required to validate its efficacy and establish standardized protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09226028251412573","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:55:12Z","timestamp":1769025312000},"page":"349-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuraltherapeutic Medicine in Post-Acute COVID-19 Vaccination Syndrome (PACVS): A Critical Review with a Case Report"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1366-5824","authenticated-orcid":false,"given":"Carlos","family":"Bustamante","sequence":"first","affiliation":[{"name":"Advanced Integrative Medicine Institute, Bogot\u00e1, Colombia"},{"name":"Universidad Nacional de Colombia, Faculty of Medicine, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Bibiana","family":"Pinilla-Bonilla","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Colombia, Faculty of Medicine, Bogot\u00e1, Colombia"},{"name":"Integrated Health services Subnetwork of South, Research and Innovation Center, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4906-283X","authenticated-orcid":false,"given":"Mauricio","family":"Pati\u00f1o Soler","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Colombia, Faculty of Medicine, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Estravis","sequence":"additional","affiliation":[{"name":"National University of Mar del Plata, Faculty of Medicine, Higher Diploma in Neuraltherapeutic Medicine, Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.7.943"},{"key":"e_1_3_3_3_1","doi-asserted-by":"crossref","unstructured":"Bellucci M. 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