{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:10:25Z","timestamp":1788667825187,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"JSPS KAKENHI","award":["22K12935"],"award-info":[{"award-number":["22K12935"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In this randomised controlled trial study, we aimed to preliminarily evaluate the effectiveness of purposeful activity-based electrical stimulation therapy (PA-EST) in improving independence in daily living in patients with stroke and moderate-to-severe upper limb hemiparesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted in the rehabilitation ward of Kyoto Ohara Memorial Hospital, Japan. Sixteen rehabilitation ward inpatients who experienced stroke and moderate-to-severe upper limb hemiparesis were included. In this randomised controlled trial, the participants were randomly assigned to either PA-EST or conventional occupational therapy (COT) and received a 2-month intervention. The primary outcome measures included motor, cognitive, and total scores on the functional independence measure (FIM). The secondary outcome measures included the Motor Activity Log (MAL), Amount of Use and Quality of Movement (QOM) subscales, and the Upper Extremity, Lower Extremity, and Total Fugl\u2013Meyer Assessment scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Two-way repeated measures analysis of variance revealed significant interactions for FIM-motor (p\u2009=\u20090.041), FIM-total (p\u2009=\u20090.029), and MAL-QOM (p\u2009=\u20090.005), with greater improvements in the PA-EST group than in the COT group. No significant interactions were observed for the other outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This randomised controlled trial study provides preliminary evidence that PA-EST may enhance activities of daily living independence in patients with subacute-phase stroke and moderate-to-severe upper limb hemiparesis. These findings support the clinical utility of PA-EST as a novel intervention strategy for advancing stroke rehabilitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09226028261481873","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:39:46Z","timestamp":1788536386000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Purposeful Activity-Based Electrical Stimulation Improves Activities of Daily Living in Patients with Subacute Stroke and Moderate-to-Severe Upper Limb Hemiparesis: A Pilot Randomised Controlled Trial"],"prefix":"10.1177","author":[{"given":"Seigo","family":"Minami","sequence":"first","affiliation":[{"name":"Faculty of Rehabilitation, Hyogo Medical University, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Kansai Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Faculty of Rehabilitation, Hyogo Medical University, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Baika Women's University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Horaguchi","sequence":"additional","affiliation":[{"name":"Gunma Paz University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Kyoto Ohara Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Kyoto Ohara Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Hida","sequence":"additional","affiliation":[{"name":"Osaka Kawasaki Rehabilitation University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.1.128"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/67.2.206"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2019.10.001"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2009.08.0140"},{"key":"e_1_3_2_6_1","volume-title":"Guide for use of the uniform data set for medical rehabilitation. 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Effect of purposeful activity-based electrical stimulation on auditory event-related potential in a stroke survivor with a severely paretic upper limb. Cognition and Rehabilitation, 2(1), 36\u201340.","journal-title":"Cognition and Rehabilitation"},{"issue":"1","key":"e_1_3_2_14_1","first-page":"54","article-title":"Purposeful activity-based electrical stimulation therapy promoted adaptability to daily life for a patient with moderate\/severe upper extremity paralysis after a chronic stroke: A case report","volume":"4","author":"Minami S.","year":"2023","unstructured":"Minami S., Kobayashi R., Horaguchi T., Kondo Ken. Ishimori T., Aoki H., Fukumoto Y., Sano N., Shinoda A., Hashimoto K., Aoyama T. (2023). Purposeful activity-based electrical stimulation therapy promoted adaptability to daily life for a patient with moderate\/severe upper extremity paralysis after a chronic stroke: A case report. Cognition & Rehabilitation, 4(1), 54\u201358.","journal-title":"Cognition & Rehabilitation"},{"issue":"1","key":"e_1_3_2_15_1","first-page":"29","article-title":"Effects of purposeful activity-based electrical stimulation therapy for a stroke patient with severe upper-limb paresis on cerebral hemodynamics: Trial of a home-based support program","volume":"3","author":"Minami S.","year":"2022","unstructured":"Minami S., Kobayashi R., Kondo K., Horaguchi T., Ishimori T., Aoki H., Fukumoto Y., Aoyama T. (2022). Effects of purposeful activity-based electrical stimulation therapy for a stroke patient with severe upper-limb paresis on cerebral hemodynamics: Trial of a home-based support program. 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