{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:05:11Z","timestamp":1777860311915,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Risk &amp; Safety in Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study examines anecdotal reports from online discussion forums suggesting possible links between SSRI antidepressants and loss of lean muscle mass, particularly in men. Given limited existing scientific research, this study bolsters academic discourse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Do self-reported experiences from internet forums indicate a perceived connection between SSRI use and muscle mass reductions?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A Google keyword search identified 202 posts from 14 randomly selected online antidepressant discussion forums. Posts were collected and thematically analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forum users reported difficulties in maintaining or gaining lean muscle after commencing SSRI treatment. Key themes included frustration, confusion, and attempts to rationalise perceived changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings suggest an area for further exploration, regarding the physiological impact of SSRIs on muscle composition. While reports remain anecdotal, they highlight concerns immediately relevant to both patients and healthcare professionals. As the study is based on self-reported experiences from anonymous sources, findings lack scientific validation but highlight requirements for further studies to explore prevalence and broader applicability. Research observations spotlight a need for further, structured clinical research to investigate possible effects of SSRIs on muscle mass.<\/jats:p>\n                    <jats:p>Future research should include controlled clinical trials and longitudinal studies to examine a potential association in more detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09246479251346445","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:17:52Z","timestamp":1747991872000},"page":"208-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["SSRI antidepressants and perceived loss of lean muscle in men: A qualitative exploration of some online anecdotal concerns"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-1134","authenticated-orcid":false,"given":"Nicholas Norman","family":"Adams","sequence":"first","affiliation":[{"name":"Robert Gordon University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00035"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00064-0"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2010.04.001"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2009.02.005"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00509"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50522"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.14412\/2074-2711-2020-2-48-56"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.01.002"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796019000519"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/bioe.2019.0010"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001154"},{"key":"e_1_3_5_13_2","first-page":"1","article-title":"Young people\u2019s experiences with mental health medication: a narrative review of the qualitative literature","volume":"31","author":"McMillan SS","year":"2020","unstructured":"McMillan SS, Wilson B, Stapleton H, et al. Young people\u2019s experiences with mental health medication: a narrative review of the qualitative literature. J Ment Health 2020; 31: 1\u201315.","journal-title":"J Ment Health"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.051110"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1108\/DAT-08-2019-0038"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2020.06.022"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032312"},{"key":"e_1_3_5_18_2","first-page":"1","article-title":"Mental illness on Instagram: a mixed method study to characterize public content, sentiments, and trends of antidepressant use","volume":"30","author":"Gupta R","year":"2020","unstructured":"Gupta R, Ariefdjohan M. Mental illness on Instagram: a mixed method study to characterize public content, sentiments, and trends of antidepressant use. J Ment Health 2020; 30: 1\u20138.","journal-title":"J Ment Health"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2019.10.016"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30296-2"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1628806"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1473325019840394"},{"issue":"1","key":"e_1_3_5_23_2","article-title":"Researching online forums","author":"British Sociological Association","year":"2016","unstructured":"British Sociological Association. Researching online forums. Ethics Case Study 2016; (1). https:\/\/www.britsoc.co.uk\/media\/24834\/j000208_researching_online_forums_-cs1-_v3.pdf","journal-title":"Ethics Case Study"},{"key":"e_1_3_5_24_2","volume-title":"Ethics guidelines for internet-mediated research","author":"British Psychological Society","year":"2013","unstructured":"British Psychological Society. Ethics guidelines for internet-mediated research. Leicester: British Psychological Society, 2013."},{"key":"e_1_3_5_25_2","first-page":"1","article-title":"\u2018Scraping\u2019 Reddit posts for academic research? Addressing some blurred lines of consent in growing internet-based research trend during the time of Covid-19","volume":"27","author":"Norman Adams N","year":"2022","unstructured":"Norman Adams N. \u2018Scraping\u2019 Reddit posts for academic research? Addressing some blurred lines of consent in growing internet-based research trend during the time of Covid-19. Int J Soc Res Methodol 2022; 27: 1\u201316.","journal-title":"Int J Soc Res Methodol"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-56015-1_369-1"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2014.933984"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920030-00007"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.3233\/JRS-180018"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.11.014"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091777"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719110385708"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200636100-00006"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.2.573S"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1123\/ijsn.5.s1.s29"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/1178646920936279"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.2.553S"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900025475"},{"key":"e_1_3_5_39_2","first-page":"343","article-title":"Evaluation of the androgenic\/antiandrogenic activity of selective serotonin reuptake inhibitors","volume":"63","author":"Pop A","year":"2015","unstructured":"Pop A, Lupu D, Cherfan J, et al. Evaluation of the androgenic\/antiandrogenic activity of selective serotonin reuptake inhibitors. FARMACIA 2015; 63: 343\u2013348.","journal-title":"FARMACIA"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00443"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5050-1"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.024"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab862"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24085"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bodyim.2020.02.003"},{"issue":"3","key":"e_1_3_5_46_2","first-page":"45","article-title":"Excessive use of Instagram causing anxiety and depression among young adults","volume":"50","author":"Ramzan M","year":"2019","unstructured":"Ramzan M, Arshad J, Adeeb H, et al. Excessive use of Instagram causing anxiety and depression among young adults. Pakistan Libr Inform Sci J 2019; 50(3): 45\u201348.","journal-title":"Pakistan Libr Inform Sci J"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bodyim.2016.08.007"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11199-018-0993-6"},{"issue":"1","key":"e_1_3_5_49_2","first-page":"10","article-title":"Girls, Instagram, and the glamorization of self-loathing","volume":"4","author":"Tanner E","year":"2015","unstructured":"Tanner E. Girls, Instagram, and the glamorization of self-loathing. Dissenting Voices 2015; 4(1): 10.","journal-title":"Dissenting Voices"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.04.006"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066480703252448"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180426153940"}],"container-title":["International Journal of Risk &amp; Safety in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09246479251346445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09246479251346445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09246479251346445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:45:46Z","timestamp":1777509946000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09246479251346445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/09246479251346445"],"URL":"https:\/\/doi.org\/10.1177\/09246479251346445","relation":{},"ISSN":["0924-6479","1878-6847"],"issn-type":[{"value":"0924-6479","type":"print"},{"value":"1878-6847","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}