{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:08:39Z","timestamp":1779430119689,"version":"3.53.1"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Risk &amp; Safety in Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The article describes a case of methemoglobinemia in a 4-year-old child with nephrotic syndrome with simultaneous use of therapeutic doses of three drugs that cause methemoglobinemia: lidocaine (topically), benzocaine (topically), and co-trimoxazole (systemically). An increase in the level of methemoglobin in the blood to 47.6% led to the development of respiratory failure. To correct the child\u2019s condition, high-flow oxygen therapy was performed and ascorbic acid was administered. During the day, there was a positive trend, the level of methemoglobin decreased to 1.5%. Toxicological examination of urine showed the presence of lidocaine, benzocaine, and trimethoprim. Thus, in conditions of polypragmasia in a child with comorbidity, the simultaneous use of three drugs with the potential of methemoglobinemia caused a significant increase in the level of methemoglobin and the development of respiratory failure, which required hospitalization in the intensive care unit. After 2\u00a0days, the patient\u2019s condition stabilized and he was transferred to a specialized department. As far as we know, this is the first documented case of methemoglobinemia in a child with polypragmasia.\n                  <\/jats:p>","DOI":"10.1177\/09246479251405948","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:40:31Z","timestamp":1776429631000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug-induced methemoglobinemia in a child with comorbidity and polypragmasia: Case report"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-0450","authenticated-orcid":false,"given":"Alina B.","family":"Strok","sequence":"first","affiliation":[{"name":"Russian Children\u2019s Clinical Hospital of Pirogov Russian National Research Medical University"},{"name":"Peoples\u2019 Friendship University of Russia Named After Patrice Lumumba (RUDN), Department of General and Clinical Pharmacology, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-1539","authenticated-orcid":false,"given":"Maria N.","family":"Kostyleva","sequence":"additional","affiliation":[{"name":"Russian Children\u2019s Clinical Hospital of Pirogov Russian National Research Medical University"},{"name":"Pirogov Russian National Research Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6889-9697","authenticated-orcid":false,"given":"Anna V.","family":"Kostina","sequence":"additional","affiliation":[{"name":"Russian Children\u2019s Clinical Hospital of Pirogov Russian National Research Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2021.103299"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2024.05.001"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05364-6"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.18.1977"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-248013"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2024.04.001"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004411"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00139709-200322010-00003"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318187c4b1"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2010.01336.x"},{"key":"e_1_3_6_12_2","first-page":"228","article-title":"Multi-center retrospective evaluation of oral benzocaine exposure in children","volume":"42","author":"Spiller HA","year":"2000","unstructured":"Spiller HA, Revolinski DH, Winter ML, et al. 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