{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:08:42Z","timestamp":1779361722898,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Risk &amp; Safety in Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute coronary syndrome remains a leading cause of mortality, making antiplatelet therapy crucial for the treatment and secondary prevention of this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to analyze consumption of antiplatelet drugs in the outpatient segment of the pharmaceutical market in the Republic of Tatarstan in 2018 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design<\/jats:title>\n                    <jats:p>We conducted a descriptive study based on sales data for antiplatelet drugs from two major suppliers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Consumption was calculated in milligrams and defined daily doses. To assess therapy coverage, we calculated standard course doses for dual antiplatelet therapy and monotherapy based on clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, we identified a significant increase in the consumption of all antiplatelet drugs. Acetylsalicylic acid consumption doubled. Among P2Y\n                      <jats:sub>12<\/jats:sub>\n                      -receptor inhibitors, clopidogrel showed the highest absolute increase (2.5 times), while ticagrelor (3.2 times) and prasugrel (4 times) showed the highest relative growth rates. The estimated number of patients who could have been treated with the sold volumes of antiplatelet drugs in 2018 was 15.4 times, and in 2023 was 35.2 times higher than the official number of registered ACS patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observe a significant increase in outpatient antiplatelet drug consumption, reflecting current trends toward expanding indications and increasing therapy duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09246479251409027","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:33:17Z","timestamp":1766485997000},"page":"265-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacoepidemiological analysis of antiplatelet drug consumption in outpatient practice"],"prefix":"10.1177","volume":"37","author":[{"given":"Dariya V.","family":"Ivanova","sequence":"first","affiliation":[{"name":"Kazan State Medical University"},{"name":"Interregional Clinical Diagnostic Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayrat Usmanovich","family":"Ziganshin","sequence":"additional","affiliation":[{"name":"Kazan State Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rustem N.","family":"Khairullin","sequence":"additional","affiliation":[{"name":"Interregional Clinical Diagnostic Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-0705","authenticated-orcid":false,"given":"Liliya Eugenevna","family":"Ziganshina","sequence":"additional","affiliation":[{"name":"Kazan State Medical University"},{"name":"Interregional Clinical Diagnostic Center"},{"name":"Department of General and Clinical Pharmacology, Peoples\u2019 Friendship University of Russia Named After Patrice Lumumba (RUDN University)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae466"},{"key":"e_1_3_3_3_2","unstructured":"Information on the health status of the population and the organization of healthcare in the Republic of Tatarstan in 2023 [Electronic resource]. \u2013 URL:. https:\/\/yandex.ru\/docs\/ access date: 01.09.2025."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-024-01036-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv511"},{"key":"e_1_3_3_6_2","unstructured":"Non-ST-segment elevation acute coronary syndrome: clinical guidelines [electronic resource]\/approved by the Ministry of Health of Russia. 2024. URL:. https:\/\/cr.minzdrav.gov.ru\/recomend\/ access date: 01.09.2024."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2474"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.0877"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-24-00973"},{"key":"e_1_3_3_10_2","unstructured":"Antiplatelet drugs market \u2013 industry trends and forecast to 2030 [electronic resource]\/data bridge market research. \u2013 2023. URL:. https:\/\/www.databridgemarketresearch.com\/reports\/global-antiplatelet-drugs-market access date: 01.09.2024."},{"key":"e_1_3_3_11_2","unstructured":"Analysis of the pharmaceutical market for January 2025: [Electronic resource]. URL:. https:\/\/dsm.ru\/docs\/analytics\/january_2025_pharmacy_analysis.pdf"},{"key":"e_1_3_3_12_2","article-title":"On the results of the healthcare sector activities in the Republic of Tatarstan in 2018 and tasks for 2019 [electronic resource]","author":"Sadykov MN","unstructured":"Sadykov MN. On the results of the healthcare sector activities in the Republic of Tatarstan in 2018 and tasks for 2019 [electronic resource]. Ministry of Health of the Republic of Tatarstan, URL:. https:\/\/minzdrav.tatarstan.ru\/file\/File access date: 04 08 2025.","journal-title":"Ministry of Health of the Republic of Tatarstan"},{"key":"e_1_3_3_13_2","unstructured":"Reference on the results of the healthcare system activities in the Republic of Tatarstan in 2023 [Electronic resource] Ministry of Health of the Republic of Tatarstan. \u2013 URL:. https:\/\/minzdrav.tatarstan.ru\/file\/minzdrav\/File access date: 05.08.2025."},{"key":"e_1_3_3_14_2","unstructured":"Results of the pharmaceutical service activities in the Republic of Tatarstan for 2019 and tasks for 2020 [electronic resource]. URL:. https:\/\/minzdrav.tatarstan.ru\/file\/pub\/pub_2276803.pdf access date: 05.03.2025."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"issue":"13","key":"e_1_3_3_16_2","first-page":"e771","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"151","author":"Rao SV","year":"2025","unstructured":"Rao SV, O'Donoghue ML, Ruel M, et al. 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines. 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