{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:10:31Z","timestamp":1788667831358,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Indonesian Education Scholarship, Center for Higher Education Funding","award":["No.00226\/BPPT\/BPI.06\/01\/2025."],"award-info":[{"award-number":["No.00226\/BPPT\/BPI.06\/01\/2025."]}]},{"name":"Ministry of Higher Education, Science, and Technology of Republic Indonesia","award":["No.00226\/BPPT\/BPI.06\/01\/2025."],"award-info":[{"award-number":["No.00226\/BPPT\/BPI.06\/01\/2025."]}]},{"DOI":"10.13039\/501100014538","name":"Indonesia Endowment Fund for Education","doi-asserted-by":"crossref","award":["No.00226\/BPPT\/BPI.06\/01\/2025."],"award-info":[{"award-number":["No.00226\/BPPT\/BPI.06\/01\/2025."]}],"id":[{"id":"10.13039\/501100014538","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Risk &amp; Safety in Medicine"],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    There are four pillars in the treatment of heart failure. During treatment, heart failure patients generally require therapy adjustment, which was deprescribing practice.\n                    <jats:bold>Aim:<\/jats:bold>\n                    This review aimed to study outcomes from deprescribing of beta blockers and renin-angiotensin aldosterone system inhibitors (RAASIs) in heart failure patients.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A narrative review was carried out. The search was conducted in May 2025, using Pubmed, Cochrane Library, and Scopus. Eligible studies included randomized controlled trials (RCTs), observational studies, and retrospective studies. Interventions included deprescribing of guideline-directed medical therapy (GDMT), or beta blocker, or RAASIs. Only articles published in English between 2015 and 2025 were included in the search.\n                    <jats:bold>Results:<\/jats:bold>\n                    The search and screening resulted in seven evaluable articles.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The current review shows that negative outcomes from deprescribing of beta blockers or RAASIs were dominant. Other measures were, therefore, needed to be taken into consideration for a better benefit\/risk balance.\n                  <\/jats:p>","DOI":"10.1177\/09246479261481001","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:13:26Z","timestamp":1788520406000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Deprescribing of beta-blocker and RAAS inhibitors in heart failure patients: A narrative review"],"prefix":"10.1177","author":[{"given":"Vina","family":"Septiani","sequence":"first","affiliation":[{"name":"School of Pharmacy, Institut Teknologi Bandung, Bandung, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Amalia","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Institut Teknologi Bandung, Bandung, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Rizki","family":"Akbar","sequence":"additional","affiliation":[{"name":"Universitas Padjajaran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusnandar","family":"Anggadiredja","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Institut Teknologi Bandung, Bandung, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"issue":"18","key":"e_1_3_3_2_2","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich PA","year":"2022","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines. 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Initiation, continuation, or withdrawal of angiotensin-converting enzyme inhibitors\/Angiotensin receptor blockers and outcomes in patients hospitalized with heart failure with reduced ejection fraction. J Am Heart Assoc 2016; 6(2): e004675. https:\/\/doi.org\/10.1161\/JAHA.116.004675","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"e_1_3_3_21_2","first-page":"163","article-title":"The impact of discontinuation of sacubitril valsartan and shifting to angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in patients with heart failure with reduced ejection fraction","volume":"25","author":"Amin OA","year":"2021","unstructured":"Amin OA, Alaarag AF. The impact of discontinuation of sacubitril valsartan and shifting to angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in patients with heart failure with reduced ejection fraction. 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