{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:58:50Z","timestamp":1785239930535,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Anhui Provincial Health Commission Subject","award":["AHWJ2023A30243"],"award-info":[{"award-number":["AHWJ2023A30243"]}]},{"name":"Fuyang Municipal Health Commission Subject","award":["FY2021-076"],"award-info":[{"award-number":["FY2021-076"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Primary\n                      \n                      \n                      open-angle glaucoma (POAG) is a chronic, progressive and irreversible eye disease. Currently, there is no effective way to prevent optic nerve damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study explored POAG gene markers to identify high-risk groups at an early stage and to find new effective therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The mRNA and clinical information of POAG patients and normal samples were downloaded from the Gene Expression Omnibus (GEO) database. Through Weighted correlation network analysis (WGCNA) and generalized linear models (GLM), random forests (RF), support vector machines (SVM), and extreme gradient boosting (xGB) models, key risk genes were identified and an early diagnosis model was established. Functional enrichment analysis and CIBERSORT algorithm were used to further reveal the changes in the POAG immune environment and find emerging therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HERPUD1, IQCK, MRPL40, SRSF7 and TMEM243 were identified as risk genes, and the prediction model and nomogram constructed based on them had good early prediction efficiency. At the mechanistic level, the heterogeneity of T cell subsets seems to be a key factor affecting the progression of POAG and has potential therapeutic value.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusions:<\/jats:bold>\n                      HERPUD1, IQCK, MRPL40, SRSF7, and TMEM243 are of great significance for the early prediction and disease progression of POAG and have the potential value of becoming therapeutic targets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329241292914","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T08:35:00Z","timestamp":1734510900000},"page":"1396-1407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Core genes and immune dysregulation in primary open-angle glaucoma: A molecular insight"],"prefix":"10.1177","volume":"33","author":[{"given":"Zhongmin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Affiliated First Hospital of Fuyang Normal University, Fuyang Normal University, Fuyang, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated First Hospital of Fuyang Normal University, Fuyang Normal University, Fuyang, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated First Hospital of Fuyang Normal University, Fuyang Normal University, Fuyang, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated First Hospital of Fuyang Normal University, Fuyang Normal University, Fuyang, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated First Hospital of Fuyang Normal University, Fuyang Normal University, Fuyang, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Affiliated First Hospital of Fuyang Normal University, Fuyang Normal University, Fuyang, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Anhui University of Science and Technology, Huainan, Anhui Province, China<?pag \\vspace*{6pt}?>"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Primary open-angle glaucoma preferred practice pattern\u00ae","volume":"128","author":"Gedde SJ","year":"2021","unstructured":"Gedde SJ, Vinod K, Wright MM,\u00a0et al. 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