{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:58:21Z","timestamp":1782561501392,"version":"3.54.5"},"reference-count":69,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jilin Province Science and Technology Development Plan Project","award":["YDZJ202301ZYTS463"],"award-info":[{"award-number":["YDZJ202301ZYTS463"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The direct association between Parkinson's disease (PD) and Myocardial infarction (MI) has been the subject of relatively limited research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to identify the genes most associated with PD and MI to explore their common pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The gene expression profiles of PD and MI were downloaded from GEO database. Differential expression analysis was performed to identify the common differential expression genes (DEGs) of PD and MI, followed by functional annotation. Subsequently, protein-protein interaction network were constructed, and hub DEGs were identified based on CytoHubba plugin and LASSO regression analysis. To explore the potential molecular mechanism of hub DEGs, GSEA analysis, immune correlation analysis, drug prediction and molecular docking were performed, and transcription factors (TF) and lncRNA-miRNA-mRNA (ceRNA) regulatory networks were constructed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 48 DEGs with the same expression trend were identified in the MI vs. normal control (NC) and PD vs. NC groups. Functional annotation results showed that the common DEGs were significantly enriched in immune and inflammation-related pathways. RPS4Y1 and UTY were the most relevant hub DEGs for PD and MI, and may be involved in the HALLMARK_MYC_TARGETS_V1 and HALLMARK_PROTEIN_SECRETION pathways. TP63 was a common TF of RPS4Y1 and UTY. The PVT1\/KCNQ1OT1-hsa-miR-31-5p-RPS4Y1 and KCNQ1OT1-hsa-let-7a-5p\/hsa-miR-19b-3p-UTY axes may play an important role in regulating PD and MI. CYCLOHEXIMIDE and ATALAREN may be potential drugs for the treatment of PD and MI comorbidity. In addition, PD and MI exhibit different patterns of immune cell infiltration and immune function status, which may be related to the specific pathological processes of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed for the first time that RPS4Y1 and UTY may be common biomarkers of PD and MI and may be potential therapeutic targets. This study provides new perspective on the common molecular mechanisms between PD and MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329241307805","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T01:52:26Z","timestamp":1738806746000},"page":"1878-1894","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Uncovering potential molecular markers and pathological mechanisms of Parkinson's disease and myocardial infarction based on bioinformatics analysis"],"prefix":"10.1177","volume":"33","author":[{"given":"Jian","family":"Liu","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xing","sequence":"additional","affiliation":[{"name":"Experimental Center of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianye","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7753-2618","authenticated-orcid":false,"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Changchun Hospital of Traditional Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Changchun Hospital of Traditional Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenan","family":"Chen","sequence":"additional","affiliation":[{"name":"Experimental Center of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Experimental Center of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030551"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071687"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-017-0183-5"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30287-X"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","unstructured":"Dong-Chen X Yong C Yang X et al. Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 2023; 8: 73.","DOI":"10.1038\/s41392-023-01353-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1199"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.008"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130230"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008720"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1038"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03231-w"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.019"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","unstructured":"Schumacher D Kramann R. Multiomic spatial mapping of myocardial infarction and implications for personalized therapy. Arterioscler Thromb Vasc Biol 2023; 43: 192\u2013202.","DOI":"10.1161\/ATVBAHA.122.318333"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225ab66"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.09.021"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2021.0195"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2015527"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/09603271221124099"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby063"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-010-9352-6"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","unstructured":"Moradi S Tapak L. Identification of novel noninvasive diagnostics biomarkers in the Parkinson's diseases and improving the disease classification using support vector machine. Biomed Res Int 2022; 2022: 5009892.","DOI":"10.1155\/2022\/5009892"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3934\/Neuroscience.2019.4.333"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-024-01885-9"},{"key":"e_1_3_4_27_2","first-page":"398","article-title":"Identifying distinct candidate genes for early Parkinson\u2019s disease by analysis of gene expression in whole blood","volume":"35","author":"Sun A-G","year":"2014","unstructured":"Sun A-G, Wang J, Shan Y-Z, et\u00a0al. Identifying distinct candidate genes for early Parkinson\u2019s disease by analysis of gene expression in whole blood. Neuro Endocrinol Lett 2014; 35: 398\u2013404.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","unstructured":"Roch\u00edn-Hern\u00e1ndez LJ Jim\u00e9nez-Acosta MA Ram\u00edrez-Reyes L et al. The proteome profile of olfactory ecto-mesenchymal stem cells-derived from patients with familial Alzheimer's disease reveals new insights for AD study. Int J Mol Sci 2023; 24: 12606.","DOI":"10.3390\/ijms241612606"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S329209"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13144"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-022-01221-z"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.26599\/1671-5411.2023.05.004"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","unstructured":"Cunningham CM Li M Ruffenach G et al. Y-Chromosome gene Uty protects against pulmonary hypertension by reducing proinflammatory chemokines. Am J Respir Crit Care Med 2022; 206: 186\u2013196.","DOI":"10.1164\/rccm.202110-2309OC"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","unstructured":"Marinkovic T Marinkovic D. Obscure involvement of MYC in neurodegenerative diseases and neuronal repair. Mol Neurobiol 2021; 58: 4169\u20134177.","DOI":"10.1007\/s12035-021-02406-w"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080583"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.20-439"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","unstructured":"Fayyad M Salim S Majbour N et\u00a0al. Parkinson's disease biomarkers based on \u03b1-synuclein. 2019; 150: 626\u2013636.","DOI":"10.1111\/jnc.14809"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","unstructured":"Venugopal H Hanna A Humeres C et al. Properties and functions of fibroblasts and myofibroblasts in myocardial infarction. Cells 2022; 11: 1386.","DOI":"10.3390\/cells11091386"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150006"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.150045sg"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","unstructured":"Kolur V Vastrad B. Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis. BMC Cardiovasc Disord 2021; 21: 329.","DOI":"10.1186\/s12872-021-02146-8"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69064-5"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.01.042"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001878"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-03954-4"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.571"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763323"},{"key":"e_1_3_4_49_2","first-page":"7855","article-title":"Knockdown of long non-coding RNA PVT1 induces apoptosis and cell cycle arrest in clear cell renal cell carcinoma through the epidermal growth factor receptor pathway","volume":"15","author":"Li W","year":"2018","unstructured":"Li W, Zheng Z, Chen H, et\u00a0al. Knockdown of long non-coding RNA PVT1 induces apoptosis and cell cycle arrest in clear cell renal cell carcinoma through the epidermal growth factor receptor pathway. Oncol Lett 2018; 15: 7855\u20137863.","journal-title":"Oncol Lett"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020430"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.747802"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167454"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.05.053"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900310R"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.07.007"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141123086"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9145-y"},{"key":"e_1_3_4_58_2","first-page":"451","article-title":"Circular RNA_101237 mediates anoxia\/reoxygenation injury by targeting let-7a-5p\/IGF2BP3 in cardiomyocytes","volume":"45","author":"Gan J","year":"2020","unstructured":"Gan J, Yuan J, Liu Y, et\u00a0al. Circular RNA_101237 mediates anoxia\/reoxygenation injury by targeting let-7a-5p\/IGF2BP3 in cardiomyocytes. Int J Mol Med 2020; 45: 451\u2013460.","journal-title":"Int J Mol Med"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.08.140"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4098-3"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0471-2"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443053"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-022-00333-x"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071676"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02723-y"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01685-w"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69010322.x"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6499-0_14"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.0939"},{"key":"e_1_3_4_70_2","doi-asserted-by":"crossref","unstructured":"McDonald CM Muntoni F. Ataluren delays loss of ambulation and respiratory decline in nonsense mutation duchenne muscular dystrophy patients. J Comp Eff Res 2022; 11: 139\u2013155.","DOI":"10.2217\/cer-2021-0196"}],"container-title":["Technology and Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09287329241307805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09287329241307805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09287329241307805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:25:45Z","timestamp":1777670745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09287329241307805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/09287329241307805"],"URL":"https:\/\/doi.org\/10.1177\/09287329241307805","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]}}}