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The causal relationship between pregnancy hypertension and schizophrenia remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the causal relationship between pregnancy hypertension and schizophrenia using a two-sample Mendelian randomization (MR) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Pregnancy hypertension (cases\/controls: 7686\/115,8993) was considered as exposure and schizophrenia (cases\/controls: 76755\/243,649) as outcome. A two-sample MR study genetically estimated associations, with the inverse variance-weighted method as primary analysis. A two-step MR study explored potential mediators. Sensitivity tests assessed pleiotropy, heterogeneity, and stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four single nucleotide polymorphisms (SNPs) were identified as genetic instruments for pregnancy hypertension (P\u2009&lt;\u20095\u2009\u00d7\u200910\n                      <jats:sup>-8<\/jats:sup>\n                      , r\u00b2\u2009&lt;\u20090.001). Pregnancy hypertension increased the risk of schizophrenia (odds ratio\u2009=\u20091.098, 95% CI\u2009=\u20091.025\u20131.173, P\u2009=\u20090.007), while reverse MR analysis found no significant link (odds ratio\u2009=\u20091.03, 95% CI\u2009=\u20090.980\u20131.082, P\u2009=\u20090.235). The two-step study revealed pregnancy hypertension elevated levels of 1,4-Dihydroxy-2-naphthoic acid (odds ratio\u2009=\u20091.351, 95% CI\u2009=\u20091.097\u20131.664, P\u2009=\u20090.004), which decreased schizophrenia risk (odds ratio\u2009=\u20090.97, 95% CI\u2009=\u20090.942\u20130.998, P\u2009=\u20090.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pregnancy hypertension is a high-risk factor for schizophrenia, with 1,4-Dihydroxy-2-naphthoic acid potentially mitigating this effect. These findings offer insights for the prophylaxis of schizophrenia and highlight the need for further research into underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09287329251316227","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:01:47Z","timestamp":1740016907000},"page":"1926-1937","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Mendelian randomization approach for advancing healthcare innovation: From pregnancy hypertension to schizophrenia"],"prefix":"10.1177","volume":"33","author":[{"given":"Wenjie","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqi","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chongqing Angel Women's &amp; Children's Hospital, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangxue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/THC-220904"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.28"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20994"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx118"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20440"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0405-x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_57"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.07.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.06.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.09.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-021-01141-w"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04434-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19050527"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.844098"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.126"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12633"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000508036"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027100"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005526"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14140"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579419000944"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-081219-103805"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13162"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13127"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.12.123"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332260"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-023-03252-w"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.04.106"},{"key":"e_1_3_3_31_2","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies NM","year":"2018","unstructured":"Davies NM, Holmes MV, Davey SG. 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